Actively Recruiting
Efficacy of Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block Versus Bilateral Lateral Quadratus Lumborum Plane Block in Controlling Post-Operative Pain in Cancer Patients Undergoing Open Nephrectomy
Led by National Cancer Institute, Egypt · Updated on 2025-03-21
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effectiveness of two types of bilateral ultrasound-guided quadratus lumborum plane blocks (intramuscular QL4 and lateral QL1) for managing postoperative pain in cancer patients undergoing open nephrectomy. This study focuses on comparing these nerve block techniques to help reduce pain after surgery, which can be distressing and lead to complications. The trial is led by the National Cancer Institute, Egypt and is randomized with double masking to ensure unbiased results. Participants will be randomly assigned to one of three groups: one receiving the bilateral intramuscular quadratus lumborum block with bupivacaine after general anesthesia, another receiving the bilateral lateral quadratus lumborum block with the same anesthetic dose, or a control group receiving only general anesthesia without any block. The blocks are given after the induction of general anesthesia. The study aims to evaluate pain control methods applied immediately post-surgery. During the 24 hours after surgery, participants will be monitored for pain levels, morphine and fentanyl consumption, changes in heart rate and blood pressure, nausea and vomiting, timing of the first rescue pain medication, and any complications related to the blocks or morphine use. Patient satisfaction will also be assessed. Safety and efficacy will be closely observed through these measures, supporting a comprehensive evaluation of pain control after surgery.
CONDITIONS
Brief Title
Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block Versus Bilateral Lateral Quadratus Lumborum Plane Block in Controlling Postoperative Pain in Cancer Patients Undergoing Open Nephrectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age from 18 to 65 years
- Both sexes
- American Society of Anesthesiology (ASA) physical status II-III
- Body mass index (BMI) between 20 and 40 kg/m2
- Scheduled for midline incision unilateral open nephrectomy surgery
You will not qualify if you...
- Patient refusal
- Age less than 18 years or greater than 65 years
- Body mass index (BMI) less than 20 kg/m2 or greater than 40 kg/m2
- Known allergy or contraindication to study drugs
- Contraindication to regional anesthesia such as local infection at injection site, peripheral neuropathies, or bleeding disorders
- American Society of Anesthesiology (ASA) physical status IV
- Use of chronic analgesic therapy (daily morphine 30 mg or equivalent, opioids, tramadol, or neuropathic pain medications)
- History of drug abuse
- Neuropsychiatric diseases or chronic pain syndromes like fibromyalgia
- Patients expected to have severe intra- or post-operative bleeding or require postoperative mechanical ventilation
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Duration of surgery and immediate post-operative period
Participants will receive bilateral ultrasound-guided intramuscular or lateral quadratus lumborum block with an injection of bupivacaine after induction of general anesthesia, or general anesthesia alone during open nephrectomy surgery.
1 surgical visit (in-person)
Duration - 24 hours postoperatively
Participants are monitored for pain control, analgesic use, vital signs, nausea and vomiting, complications, and satisfaction for 24 hours after surgery.
Assessments during the 24-hour hospital stay after surgery
Trial Site Locations
Total: 1 location
1
National Cancer Institute
Cairo, Egypt, 11796
Actively Recruiting
Research Team
A
Ahmed M Salama, Master
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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