Comparing Two Types of Ultrasound-Guided Quadratus Lumborum Plane Blocks for Pain Control After Open Nephrectomy in Cancer Patients

What this Trial Is About

Researchers are studying the effectiveness of two types of bilateral ultrasound-guided quadratus lumborum plane blocks intramuscular QL4 and lateral QL1 for managing postoperative pain in cancer patients undergoing open nephrectomy. This study focuses on comparing these nerve block techniques to help reduce pain after surgery, which can be distressing and lead to complications. The trial is led by the National Cancer Institute, Egypt and is randomized with double masking to ensure unbiased results. Participants will be randomly assigned to one of three groups one receiving the bilateral intramuscular quadratus lumborum block with bupivacaine after general anesthesia, another receiving the bilateral lateral quadratus lumborum block with the same anesthetic dose, or a control group receiving only general anesthesia without any block. The blocks are given after the induction of general anesthesia. The study aims to evaluate pain control methods applied immediately post-surgery. During the 24 hours after surgery, participants will be monitored for pain levels, morphine and fentanyl consumption, changes in heart rate and blood pressure, nausea and vomiting, timing of the first rescue pain medication, and any complications related to the blocks or morphine use. Patient satisfaction will also be assessed. Safety and efficacy will be closely observed through these measures, supporting a comprehensive evaluation of pain control after surgery.

Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block Versus Bilateral Lateral Quadratus Lumborum Plane Block in Controlling Postoperative Pain in Cancer Patients Undergoing Open Nephrectomy