Actively Recruiting

Phase Not Applicable
FEMALE
ID07352761

Comparing Different Techniques of Bilateral Uterine Artery Occlusion During Laparoscopic Myomectomy: A Randomized Controlled Trial

Led by Alexandria University · Updated on 2026-01-20

60

Participants Needed

2

Research Sites

4 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating different techniques of bilateral uterine artery occlusion during laparoscopic myomectomy in women with uterine fibroids. The study aims to determine whether these techniques reduce blood loss during surgery and affect postoperative hemoglobin levels and ovarian reserve. This randomized controlled trial compares three occlusion methods against a control group without occlusion to assess their impact on surgical outcomes and ovarian health. Participants will be randomly assigned to one of four groups: temporary clipping of both uterine arteries, temporary occlusion using a shoelace suture technique, permanent occlusion with bipolar coagulation, or no occlusion (control group). Each procedure is performed just before or during laparoscopic myomectomy as appropriate for the assigned technique. The interventions focus on controlling blood flow to the uterus to minimize bleeding during the fibroid removal surgery. During the study, participants will undergo laparoscopic myomectomy with the assigned artery occlusion technique. Researchers will measure intraoperative blood loss during and shortly after surgery and track changes in hemoglobin 24 hours post-operation. They will also assess operative times for artery occlusion and total surgery, monitor ovarian reserve three months after surgery, and record any complications during and after the procedure. The study is conducted at two gynecological centers, with follow-up assessments extending up to three months post-surgery.

CONDITIONS

Brief Title

Bilateral Uterine Artery Occlusion During Laparoscopic Myomectomy

Who Can Participate

FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Women with uterine fibroids experiencing abnormal uterine bleeding, infertility, or pressure symptoms on urinary or rectosigmoid areas
  • Fibroids measuring between 3 and 10 centimeters in diameter
  • Having three or fewer fibroids
Not Eligible

You will not qualify if you...

  • Contraindications to pneumoperitoneum and laparoscopy
  • Body mass index (BMI) greater than 30 kg/m2
  • History of midline abdominal surgeries
  • Prior ovarian surgery
  • Hormonal treatment within 3 months before surgery
  • Not suitable candidates for myomectomy due to multiple (4 or more) fibroids, adenomyosis, or recurrent fibroids
  • Suspected endometrial cancer or leiomyosarcoma based on imaging
  • Presence of submucous fibroids requiring hysteroscopic myomectomy along with laparoscopy

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Treatment

Duration - Duration of the surgical procedure

Participants undergo laparoscopic myomectomy with one of the following techniques for bilateral uterine artery occlusion: temporary clipping, temporary occlusive suturing, bipolar coagulation, or no occlusion (control).

1 surgical procedure visit (in-person)

Follow-up

Duration - Up to 3 months postoperatively

Participants are monitored for postoperative outcomes including hemoglobin levels, ovarian reserve, and complications.

Several follow-up visits up to 3 months after surgery

Trial Site Locations

Total: 2 locations

1

Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria Univeristy

Alexandria, El-Shatby, Egypt, 21723

Actively Recruiting

2

• Al-Madina Women Hospital, A specialized hospital of Obstetrics and Gynecology, Alexandria, Egypt.

Alexandria, Smouha, Egypt

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Research Team

A

Ahmed Shoukry, MD/PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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