Using Placental Tissue Grafts in Living Donor Liver Transplants to Improve Bile Duct Healing and Reduce Complications

What this Trial Is About

Researchers are studying the safety and effects of using placental tissue grafts in adults undergoing living donor liver transplants. This pilot study aims to see if applying MiMedx placental tissue grafts around the bile duct connection can reduce biliary complications after transplant. The study also evaluates rates of postoperative complications and outcomes within one year after transplant. Participants will receive a living donor liver transplant following standard procedures, with the addition of MiMedx AmnioFix placental tissue graft placed around the biliary anastomosis during surgery. This is a single-arm, non-randomized study where all participants receive this graft. The researchers will monitor participants up to one year after the transplant to assess the impact on biliary complications and other postoperative outcomes. During the study, participants will have pre-procedure, post-procedure, and follow-up visits according to usual transplant care. The study team will review medical records after each follow-up visit to track any biliary complications and other postoperative issues. Outcomes such as hospital stay length, ICU stay, and readmissions will be measured up to one year post-transplant, with safety closely monitored throughout the study period.

Biliary Anastomosis in Living Donor Liver Transplant With Amniotic Tissue