Chinese National Cohort Study on Biliary Dilatation in Patients Up to Age 80 Tracking Disease Progression, Surgical Decisions, and Outcomes by Todani Types I, IVa, and V

What this Trial Is About

Researchers are conducting a large, multicenter cohort study across 25 medical centers in China to understand biliary dilatation, a complex benign bile duct disorder common in East Asia. This study aims to establish a comprehensive Chinese cohort to clarify the diseases epidemiology, pathological features, classification, progression, cancer risk, and optimal timing for surgical intervention. It particularly focuses on different patient types classified by Todani types I, IVa, and V and seeks to develop standardized surgical treatment strategies. The study includes both retrospective and prospective cohorts. The retrospective group collects historical clinical data and outcomes of patients previously diagnosed with biliary dilatation, while the prospective group enrolls newly diagnosed patients for ongoing observation and follow-up. Data collected cover demographic details, clinical characteristics, laboratory and imaging results, biliary-specific biomarkers, and long-term follow-up records. The study compares perioperative risks, long-term outcomes, and quality of life measures across different patient subtypes and surgical approaches. Participants will provide data through medical records and follow-ups that track disease progression and surgical outcomes over time. The study monitors long-term complication rates after surgery and assesses malignant transformation and perioperative complication rates. Quality of life is also evaluated to understand patient-reported outcomes. The study aims to continue enrolling and following patients up to age 80, with data collection planned until March 2035, providing valuable insights into biliary dilatation management and treatment outcomes.

Biliary Dilatation National Special Disease Cohort in China