Actively Recruiting
The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass
Led by Prof Urs Zingg · Updated on 2025-05-15
50
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to investigate the effect of Esomeprazol administered in tablets (Esomeprazol MUT Sandoz® 40mg) or in solution (Esomeprazol MUT Sandoz® 40mg in 10ml tap water) on acid production in the gastric pouch by measuring the intragastric pH and the serum concentration of esomeprazole.
CONDITIONS
Official Title
The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Proximal Roux-en-Y gastric bypass with linear stapled anastomosis 12 months prior to the study investigation
- Routine administration of proton pump inhibitors for 6 months postoperatively
- No intake of proton pump inhibitors at least 4 weeks prior to study investigation
- No marginal ulcers in upper endoscopy prior to placement of wireless BRAVO24 pH monitoring capsule
- No symptoms related to gastro-esophageal reflux or marginal ulcers (i.e. epigastric pain, retrosternal burning, regurgitation)
- Informed consent as documented by signature
You will not qualify if you...
- Known intolerance or allergy for Esomeprazol
- Contraindication for upper endoscopy
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
- Women who are pregnant or breast feeding
- Major hepatic dysfunction
AI-Screening
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Trial Site Locations
Total: 1 location
1
Spital Limmattal
Schlieren, Switzerland, 8952
Actively Recruiting
Research Team
U
Urs Zingg, Prof.
CONTACT
P
Patrizia Heeb
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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