Goal-focused Emotion-Regulation Therapy for young adult survivors of testicular cancer: Feasibility of a behavioral intervention.
Michael A Hoyt, Christian J Nelson
https://pubmed.ncbi.nlm.nih.gov/32913918/Actively Recruiting
Led by University of California, Irvine · Updated on 2025-03-25
100
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating a new biobehavioral intervention called Goal-focused Emotion-Regulation Therapy GET for LatinoHispanic young adult males who survived cancer diagnosed between ages 15 and 39. This study compares GET to an active control called Individual Supportive Listening ISL. The goal is to improve distress symptoms, emotional regulation, goal navigation skills, and reduce stress-related biological markers. The trial builds on earlier research showing a high risk of distress and adverse outcomes in young HispanicLatino cancer survivors, aiming to address psychological and biobehavioral challenges during young adulthood. Participants will be randomly assigned to receive six sessions of GET or ISL over eight weeks. GET focuses on helping individuals set and pursue meaningful goals, regulate emotions related to cancer, and improve self-regulation skills. ISL provides supportive therapy through attentive listening and encouragement without directive advice. Both interventions are delivered individually via an interactive video platform to improve access. The study also explores how cultural factors like Familism and Acculturative Stress may influence outcomes. During the study, participants will complete assessments at baseline, immediately after the intervention, and three months later. Researchers will measure psychological outcomes such as anxiety, depression, spiritual well-being, career thoughts, and emotional coping, along with stress-sensitive biomarkers including inflammatory cytokines and salivary cortisol patterns. The study includes monitoring intervention feasibility and cultural influences. Participation will last about 20 weeks from baseline through follow-up.
CONDITIONS
A Biobehavioral Intervention for Latino/Hispanic Young Adults with Cancer
M
Michael A Hoyt, PhD
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University of California, Irvine
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | GET | ISL (Active Comparator) |
|---|---|---|
| What it is | GET is a structured, goal-focused behavioral intervention delivered individually. It helps participants clarify valued life goals, teaches strategies for navigating obstacles, and aims to improve emotional regulation, meaning, and purpose. | ISL is a non-directive, individually delivered supportive therapy. Sessions focus on attentive listening and encourage open discussion of thoughts and feelings, with the goal of supporting self-esteem and resilience. |
| Role in trial | Experimental intervention arm; being tested for its effect on distress, goal navigation ability, self-regulation, and biological stress markers in young Latino/Hispanic adults with cancer. | Active comparator arm; serves as a control to match participant contact time and attention without introducing new goal navigation or emotion regulation strategies. |
| Primary use in this context | Designed to reduce emotional distress, improve goal-setting and navigation skills, and support adaptation among Latino/Hispanic young adults affected by cancer. | Intended to provide emotional support through non-directive listening and expression, used as a common control to assess supportive effects apart from novel intervention strategies. |
| How it is given or performed | GET is delivered through individually scheduled sessions where participants discuss personal goals, barriers, and develop self-regulation strategies, following a structured protocol over approximately 8 weeks. | ISL is provided through individually matched sessions in time and frequency to GET, focusing on attentive, non-directive support and open conversation. |
| Evidence status / body of evidence | GET is undergoing study in this population; prior pilot trials in young adult cancer survivors, including testicular cancer, found GET feasible and suggested possible benefits for psychological adaptation and biological stress markers, but definitive efficacy evidence in Latino/Hispanic young adults with cancer is not established. | ISL has long-established use as an attention-matched control and supportive intervention; it supports emotional expression and understanding but does not provide specific skills training or goal navigation strategies. Its effect on distress in Latino/Hispanic young adults with cancer as a standalone therapy is not well established. |
| Important limitations | GET's evidence for efficacy in Latino/Hispanic young adults with cancer is still emerging. Previous studies in related but non-Hispanic populations suggest possible benefits, but results may not fully generalize, and this ongoing trial will address the specific population. | ISL, as a non-directive supportive approach, does not teach structured coping or goal-setting skills. Its impact on clinically meaningful distress reduction beyond supportive presence is less robust and may be limited in skill-building for adaptation. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Duration - Approximately 8 weeks
Participants receive 6 sessions of a behavioral intervention (either Goal-Focused Emotion-Regulation Therapy or Individual Supportive Listening) delivered via an interactive video platform to help manage cancer-related distress and improve emotional regulation and goal navigation skills.
6 sessions conducted individually via video platform
Duration - Approximately 12 weeks after treatment completion
Participants are assessed to evaluate the lasting effects of the intervention on distress, biobehavioral indicators, and emotional well-being.
1 follow-up visit (remote or in-person)
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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Lead Sponsor