Actively Recruiting
Led by University of California, Irvine · Updated on 2025-05-01
250
Participants Needed
1
Research Sites
N/A
Total Duration
U
University of California, Irvine
Lead Sponsor
M
Memorial Sloan Kettering Cancer Center
Collaborating Sponsor
Researchers are evaluating a new behavioral intervention called Goal-focused Emotion-Regulation Therapy (GET) aimed at reducing distress, improving emotion regulation, goal navigation skills, and stress-sensitive biomarkers in young adult men diagnosed with testicular cancer. This randomized controlled trial compares GET to Individual Supportive Listening (ISL) to understand their effects on psychological and biological outcomes. The study focuses on young adults aged 18 to 39 who have completed chemotherapy and experience distress related to their cancer. Participants will be randomly assigned to receive either six sessions of GET or ISL over eight weeks. GET helps patients identify meaningful personal goals, refine them, and develop strategies to overcome obstacles while improving emotional regulation and sense of purpose. ISL provides supportive, non-directive therapy focused on listening and encouraging expression of thoughts and feelings. Both interventions are delivered individually via an interactive video platform to improve access. During the study, participants will complete assessments at baseline, immediately after treatment, and at three- and six-month follow-ups. These include questionnaires measuring depression, anxiety, emotion regulation, goal navigation, career confusion, and spiritual well-being. Researchers will also collect biological samples to measure stress hormones and inflammatory markers. The study aims to evaluate the feasibility, acceptability, and effects of these interventions on psychological distress and biological stress indicators in young adult testicular cancer survivors.
CONDITIONS
A Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Testicular Cancer Survivors
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 8 weeks
Participants receive either the Goal-Focused Emotion-Regulation Therapy (GET) or Individual Supportive Listening (ISL) over 6 sessions to help manage distress and improve emotional regulation after testicular cancer treatment.
6 sessions delivered via an interactive video platform
Duration - Up to 6 months post-intervention
Participants are monitored to assess the lasting effects of the intervention on psychological distress, biobehavioral indicators, and goal navigation.
2 follow-up assessments at 3 months and 6 months post-intervention
Total: 1 location
1
University of California, Irvine
Irvine, California, United States, 92697-3954
Actively Recruiting
M
Michael A Hoyt, PhD
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/34514890