Actively Recruiting
Biocollection of Rare Pediatric-onset of Autoimmune and Autoinflammatory Diseases
Led by Hospices Civils de Lyon · Updated on 2025-12-22
400
Participants Needed
13
Research Sites
543 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Rare diseases are defined as those that affect one person in 2,000, or around three million people in France. The majority of rare diseases are caused by genetics and tend to be severe when they begin in childhood. Autoimmune and autoinflammatory diseases, such as systemic lupus, juvenile dermatomyositis, and juvenile idiopathic arthritis, are examples of rare pediatric diseases. While autoimmune diseases are characterized by an inappropriate adaptive immune response, autoinflammatory diseases involve an excess of the innate immune response. The precise mechanisms of these diseases are not yet fully understood, but recent research has led to advances in their diagnosis and identification, particularly in early onset and familial forms. However, the rarity of these diseases and limited availability of biological samples pose significant challenges. This study aims to create a biological collection, which includes primary cells (PBMC), DNA, RNA, lymphoblastic lines, and serum, that will help identify genetic and immunological abnormalities in rare autoimmune and autoinflammatory diseases through various research projects.
CONDITIONS
Official Title
Biocollection of Rare Pediatric-onset of Autoimmune and Autoinflammatory Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Minor or adult patient of any age with a rare dysimmune disease characterized by autoimmunity or auto-inflammation or early lymphoproliferation starting before 18 years old or with syndromic or familial forms
- Relative of a minor or adult patient with a rare dysimmune disease characterized by autoimmunity or auto-inflammation or early lymphoproliferation starting before 18 years old or with syndromic or familial forms
- Weight greater than 5 kg
- Patient or parent/guardian informed about the study and signed consent form
- Patient affiliated to a social security scheme
- Healthy volunteers of any age
- Healthy volunteers weighing over 5 kg
- Healthy volunteers informed about the study and signed consent form
- Healthy volunteers affiliated to a social security scheme
You will not qualify if you...
- Refusal by subject or parent/guardian to participate in the study
- Healthy volunteers with active viral, bacterial, or parasitic infection
- Healthy volunteers with history of cancer within the past 5 years or current cancer
- Healthy volunteers with personal or family history of autoimmune disease
- Immunocompromised participants including immune deficiency or transplant recipients
- Adults under legal protection such as guardianship or curatorship
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
Service de rhumatologie pédiatrique Hôpital Femme-Mère-enfant
Bron, Bron, France, 69500
Actively Recruiting
2
Hôpital Jeanne de Flandre (CHU de Lille)
Lille, Lille, France, 59000
Not Yet Recruiting
3
Hôpital Claude Huriez (CHU de Lille)
Lille, Lille, France, 59037
Not Yet Recruiting
4
Hôpital Archet 2
Nice, Nice, France, 06200
Not Yet Recruiting
5
Hôpital Necker-Enfants Malades (AP-HP)
Paris, Paris, France, 75015
Not Yet Recruiting
6
Hôpital Robert Debré (AP-HP)
Paris, Paris, France, 75935 Paris
Not Yet Recruiting
7
Hôpital Kremlin-Bicêtre (AP-HP)
Paris, Paris, France, 94270
Not Yet Recruiting
8
Hôpital Nord (CHU ST-Etienne)
Saint-Etienne, Saint Etienne, France
Not Yet Recruiting
9
Hôpital Couple Enfant
Grenoble, France, 38043
Not Yet Recruiting
10
Dr Isabelle MELKI
Paris, France, 75012
Actively Recruiting
11
CLCC Henri Becquerel
Rouen, France, 76038
Not Yet Recruiting
12
Pr Ariane ZALOSZYC
Strasbourg, France
Actively Recruiting
13
Dr Vanessa Remy-Piccolo
Villefranche-sur-Saône, France
Actively Recruiting
Research Team
B
BELOT Alexandre, Pr
CONTACT
P
PLASSART Samira
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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