Evaluation of the Effectiveness of Blood Concentrate Biofiller in Thickening the Gingival Phenotype Around Natural Teeth

What this Trial Is About

This research aims to compare the effectiveness of a novel blood concentrate called biofiller with connective tissue grafts in increasing gingival thickness among patients with a thin gingival phenotype. The periodontal phenotype includes gingival thickness and keratinized tissue width, with thin phenotypes being more prone to inflammation and trauma. Platelet-rich concentrates like biofiller have regenerative properties and may provide a less invasive alternative to traditional grafts. Participants will undergo a standardized tunneling surgical procedure in the mandibular anterior region (canine to canine). The test group will receive a single injection of 0.5 mL biofiller per tooth, prepared from the patient's own blood by heating platelet-poor plasma and mixing it with concentrated platelet-rich fibrin. The control group will receive autogenous connective tissue grafts harvested from the palate and placed under the gingiva through the tunnel. Both procedures are done under local anesthesia. Patients will be evaluated at baseline and at 1, 3, and 6 months after treatment. Clinical assessments include measuring gingival thickness, keratinized tissue width, and soft tissue thickness using intraoral scanners. Orthodontic evaluations and lateral cephalometric radiographs will be performed to measure bone thickness and ensure participants have a Class I skeletal relationship. The primary outcome is the change in gingival thickness over time, with safety and comfort monitored throughout the study.

Biofiller and Gingival Phenotype Thickening