Using Bioimpedance Analysis to Improve Fluid Management in Hospitalized Patients with Worsening Heart Failure

What this Trial Is About

This research aims to evaluate whether using Bioimpedance Analysis BIA can improve fluid management in patients hospitalized with worsening heart failure. The study compares BIA-guided treatment to standard care to see if this approach reduces the need for extra diuretic treatment or rehospitalization within 90 days after discharge. Heart failure affects millions worldwide, and managing fluid levels accurately is a key challenge in preventing hospital readmissions and worsening symptoms. Participants will be randomly assigned to one of two groups. The BIA-guided group will have BIA measurements performed within 24 hours of admission and throughout their hospital stay to guide fluid management and diuretic use. The standard care group will also have BIA measurements at admission and discharge, but these results will not be shared with their care team, who will manage fluid levels based on usual clinical assessments. After discharge, all patients will attend a follow-up visit 2 to 4 weeks later for health checks, blood tests including NT-proBNP, and a quality-of-life questionnaire. During the study, participants will undergo standard clinical exams, blood tests, and questionnaires to assess heart failure symptoms and quality of life. Researchers will track hospital readmissions, need for additional treatment, kidney function, length of hospital stay, and mortality up to 12 months after discharge. The main outcome is the rate of heart failure events within 90 days post discharge. Safety and long-term effects will also be monitored, with data analyzed after all participants have completed follow-up.

Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure