Actively Recruiting
Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells
Led by Jonsson Comprehensive Cancer Center · Updated on 2025-10-08
50
Participants Needed
1
Research Sites
264 weeks
Total Duration
On this page
Sponsors
J
Jonsson Comprehensive Cancer Center
Lead Sponsor
N
National Center for Advancing Translational Sciences (NCATS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this project is to validate a new combined MRI and PET imaging technique as a biomarker or measure of glycolysis in brain tumors. To accomplish this, the investigators propose obtaining image-guided measures of tissue pH and biopsied tissue in tumor areas selected for bulk resection surgery. Investigators will then correlate the imaging measurements with pH, RNA expression, protein expression, and bioenergetics measurements of key glycolytic enzymes.
CONDITIONS
Official Title
Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18
- Patients with newly diagnosed or recurrent glioblastoma clinically indicated for resective surgery
You will not qualify if you...
- Patients who cannot obtain an MRI or FDG PET scan with contrast
- Those with ferromagnetic implanted devices that might produce a safety hazard (e.g. infusion pumps, pacemakers, aneurysm clips)
- Patients with severe claustrophobia
- Patients with severely compromised renal function (GFR < 30)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California at Los Angeles
Los Angeles, California, United States, 90095-1406
Actively Recruiting
Research Team
R
Raksha Nagaraj
CONTACT
S
Saima Chaabane
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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