Actively Recruiting

Phase Not Applicable
Age: 25Years - 42Years
FEMALE
ID07404969

An Interventional Study Evaluating Telomere and Biological Aging Hallmarks Profiling to Guide an Integrative Traditional Chinese and Conventional Medicine Approach in Women With Post-Treatment Unexplained Infertility

Led by BEYOND GENOMiX SA, AG, Ltd · Updated on 2026-04-29

15

Participants Needed

1

Research Sites

13 weeks

Total Duration

On this page

Sponsors

B

BEYOND GENOMiX SA, AG, Ltd

Lead Sponsor

P

Praxis für Akupunktur und Chinesische Arzneimittel

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to explore whether profiling telomeres and other biological aging markers can reveal underlying causes of persistent infertility in women who have undergone treatment but remain unable to conceive. The study focuses on women aged 25 to 42 years with unexplained infertility despite proper management of known reproductive issues and repeated assisted reproductive technology (ART) attempts. It seeks to understand if these molecular aging indicators can define a biological aging pattern related to infertility and whether personalized integrative treatments can improve pregnancy outcomes. Participants receive baseline reproductive evaluations and blood tests to assess telomere length and aging hallmarks at the cellular level. The intervention includes a personalized integrative approach combining Traditional Chinese Medicine (TCM) herbal formulas and targeted nutritional supplements aimed at restoring cellular aging markers. This preconception phase lasts between 4 and 12 weeks, after which women attempt conception naturally or with ART such as intrauterine insemination (IUI) or in vitro fertilization (IVF), while continuing integrative support. Throughout the study, participants undergo ongoing assessments of reproductive health, molecular aging markers, and pregnancy outcomes for up to 12 months. Researchers monitor changes in telomere length, the proportion of critically short telomeres, ovarian reserve markers, and overall safety and tolerability of the intervention. The main outcome is clinical pregnancy rate per conception attempt, with secondary measures evaluating molecular and reproductive changes related to the integrative therapy.

CONDITIONS

Brief Title

Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility

Who Can Participate

Age: 25Years - 42Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Biological female participants aged 25 to 42 years
  • Diagnosis of infertility defined as failure to conceive after at least 12 months of unprotected intercourse and/or repeated failure of assisted reproductive technologies (ART), including intrauterine insemination (IUI) and/or in vitro fertilization (IVF)
  • History of post-treatment unexplained or functionally idiopathic infertility despite adequate correction of identifiable reproductive conditions
  • Eligibility for natural conception attempts and/or assisted reproductive technologies according to routine clinical practice
  • Willingness to undergo biological aging biomarker profiling including leukocyte telomere analysis
  • Ability and willingness to comply with study procedures including the preconception integrative intervention and follow-up assessments
  • Provision of written informed consent prior to participation
Not Eligible

You will not qualify if you...

  • Current pregnancy or breastfeeding at the time of enrollment
  • Known chromosomal abnormalities or genetic conditions directly impairing fertility such as Turner syndrome
  • Untreated severe male factor infertility preventing conception by natural or standard ART methods
  • Active malignancy or history of cancer requiring systemic treatment within the past 5 years
  • Severe systemic disease or medical condition contraindicating pregnancy or ART participation
  • Use of investigational drugs or participation in another interventional clinical trial that could interfere with study outcomes
  • Known hypersensitivity or contraindication to components of the integrative intervention
  • Any condition that would interfere with safe participation or interpretation of study results as judged by the investigator

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Baseline Assessment

Duration - Up to 1 week

Participants undergo comprehensive reproductive evaluation and molecular profiling including leukocyte telomere analysis to establish individual biological aging signatures relevant to fertility.

1 baseline visit (in-person)

Preconception Integrative Intervention

Duration - 4 to 12 weeks

Participants receive a personalized 4 to 12-week integrative treatment combining Traditional Chinese Medicine herbal formulations and targeted nutraceutical supplementation to restore telomere stability, improve mitochondrial function, and reduce cellular senescence in support of reproductive health.

Weekly visits for up to 12 weeks

Conception Attempt

Duration - Up to 12 months

Participants attempt to conceive naturally or via assisted reproductive technologies such as intrauterine insemination (IUI) or in vitro fertilization (IVF) while continuing integrative therapy to maintain molecular improvements and support fertility.

Visits as per routine fertility care for natural conception or ART cycles

Follow-up and Outcome Assessment

Duration - Up to 12 months

Participants are monitored for clinical pregnancy outcomes and undergo follow-up assessments of molecular and reproductive parameters to evaluate the effectiveness and safety of the integrative intervention over a period of up to 12 months.

Approximately 3 to 6 visits depending on biological response and clinical progress

Trial Site Locations

Total: 1 location

1

BEYOND GENOMiX Research and Coordination Center

Neuchâtel, Switzerland, 2000

Actively Recruiting

Loading map...

Research Team

M

M. MERARCHI

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

Similar Trials

A Prospective Study to Evaluate the Outcome of the Aurora Te...

Infertility Assisted Reproductive Technology

Actively Recruiting

1 location

Assessing the Impact of an Artificial Intelligence-Machine L...

Infertility (IVF Patients)

Actively Recruiting

1 location

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Published Research Related To This Trial

Telomere aberrations, including telomere loss, doublets, and extreme shortening, are increased in patients with infertility.

Radhia M'kacher, Bruno Colicchio, Valentine Marquet...

https://pubmed.ncbi.nlm.nih.gov/33272625