Actively Recruiting
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
Led by BEYOND GENOMiX SA, AG, Ltd · Updated on 2026-04-29
15
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
Sponsors
B
BEYOND GENOMiX SA, AG, Ltd
Lead Sponsor
P
Praxis für Akupunktur und Chinesische Arzneimittel
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether telomere profiling and other biological aging hallmarks can help identify underlying mechanisms of persistent infertility in women with post-treatment unexplained infertility. The study also evaluates whether a personalized integrative treatment guided by these biomarkers can improve reproductive outcomes. The study includes women aged 25 to 42 years who continue to experience infertility despite appropriate management of identifiable reproductive conditions and repeated attempts with assisted reproductive technologies (ART), such as intrauterine insemination (IUI) or in vitro fertilization (IVF). The main questions this study aims to answer are: * Can telomere and biological aging hallmarks profiling identify a biological aging phenotype associated with infertility? * Can an integrative treatment guided by these profiles improve clinical pregnancy outcomes? Participants will: * Undergo a baseline reproductive evaluation and blood-based assessment of telomeres and aging hallmarks. * Receive an integrative approach combining Traditional Chinese Medicine (TCM), targeted nutritional support, and standard fertility care. * Proceed with natural conception attempts or standard assisted reproductive technologies following the preconception phase. * Participants will be followed to assess pregnancy outcomes and changes in biological aging hallmarks.
CONDITIONS
Official Title
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biological female participants aged 25 to 42 years
- Infertility defined by failure to conceive after at least 12 months of unprotected intercourse or repeated failure of assisted reproductive technologies including IUI or IVF
- Persistent infertility despite adequate treatment of known reproductive conditions such as endometriosis, polycystic ovary syndrome, hormonal imbalance, or uterine factors
- Eligible for natural conception attempts and/or assisted reproductive technologies
- Willingness to undergo biological aging biomarker profiling including leukocyte telomere analysis
- Ability and willingness to follow study procedures including integrative preconception treatment and follow-up
- Provided written informed consent prior to participation
You will not qualify if you...
- Current pregnancy or breastfeeding at enrollment
- Known chromosomal abnormalities or genetic fertility-impairing conditions such as Turner syndrome
- Untreated severe male factor infertility preventing conception by natural or standard ART methods
- Active cancer or history of cancer requiring systemic treatment within past 5 years
- Severe systemic diseases or medical conditions that contraindicate pregnancy or ART participation
- Use of investigational drugs or enrollment in other interventional trials that might affect study outcomes
- Known allergies or contraindications to components of the integrative treatment
- Any condition judged by investigators to interfere with safe participation or study result interpretation
AI-Screening
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Trial Site Locations
Total: 1 location
1
BEYOND GENOMiX Research and Coordination Center
Neuchâtel, Switzerland, 2000
Actively Recruiting
Research Team
M
M. MERARCHI
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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