Actively Recruiting
Biological & Functional Signatures for Muscle Failures in Older Adults and Personalized Physical Activity: BioFaSt MAPPA
Led by Centre Hospitalier Universitaire de Nice · Updated on 2025-12-03
900
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how personalized physical activity affects muscle failure in elderly people. The study aims to identify biological markers related to muscle weakness and to tailor physical activity based on physical, biological, and psychosocial factors. It involves seniors who are healthy or frail, exploring differences in how individuals respond to exercise. Participants are randomly assigned to one of three groups: 12 weeks of adapted and personalized physical activity, 12 weeks of generic adapted physical activity, or no physical activity. The study lasts five years with each participant involved for about three months. Physical activity programs and biological assessments are used to evaluate changes. During the study, participants undergo physical assessments including geriatric exams, gait analysis, bone density scans, and cognitive tests before and after the 12-week activity period. Blood samples are collected to study metabolomic and epigenetic signatures. Psychometric questionnaires assess personality, health perception, motivation, and attitudes toward aging. Researchers measure muscle power and other muscle function indicators to track improvements and differences among the groups.
CONDITIONS
Brief Title
Biological & Fonctional Signatures for Muscle Failures, Aged People & Personalized Physical Activity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than or equal to 60 years
- Affiliated patient or beneficiary of a social security scheme
- Patient having signed a prior informed consent.
You will not qualify if you...
- Neurocognitive disorder preventing the expression of informed consent
- Patients protected by law under guardianship or curatorship, or who cannot participate in a clinical study under Article L. 1121-16 of the French Public Health Code
- Presence of a physical or cognitive pathology preventing the performance of the adapted physical activity protocol over 3 months.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants undergo 12 weeks of physical activity, which may be adapted and personalized, adapted generic, or no physical activity depending on their group assignment. Physical, biological, and psychometric assessments are conducted before and after this period.
2 visits (before and after the 12-week physical activity period)
Trial Site Locations
Total: 1 location
1
CHU de Nice
Nice, France, 06000
Actively Recruiting
Research Team
O
Olivier GUERIN, PU-PH
F
Fréderic CHORIN, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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