Impact of Biological Sex and Hormones on Right Heart Function and Recovery in Adults with Chronic Thromboembolic Pulmonary Hypertension

What this Trial Is About

Researchers are studying chronic thromboembolic pulmonary hypertension CTEPH to understand differences between biological sexes in how the right ventricle RV of the heart functions at diagnosis and recovers after surgery. The study aims to explore if sex hormone levels are related to RV function during diagnosis and recovery. This research includes both retrospective and prospective parts to gather comprehensive data on these aspects. The study includes a retrospective cohort analyzing historical patient data to assess RV function at diagnosis and after pulmonary thromboendarterectomy PTE surgery using echocardiogram strain analysis. Separately, a prospective cohort will enroll new patients to examine how sex hormone levels relate to RV function over time. The retrospective parts use past clinical databases, while the prospective part involves enrolling distinct patients and monitoring them. Participants provide clinical data including echocardiograms and right heart catheterization results at diagnosis and follow-up after surgery. Researchers will analyze heart function measures and hormone levels. The main outcomes focus on RV function patterns over one year. The study involves reviewing past records as well as collecting new clinical information, with no experimental treatments given. Participation duration varies depending on cohort involvement.

Biological Sex and CTEPH-related RV Dysfunction and Recovery (BIOSPHeRe)