Pilot Study of Single-Dose Biology-Guided Radiation Therapy for Painful Bone Metastases from Solid Cancers

What this Trial Is About

Researchers are evaluating biology-guided radiation therapy BgRT for patients experiencing painful bone metastases from cancer. This phase 1 clinical trial aims to assess the safety and effectiveness of a single-dose BgRT treatment in reducing pain and improving quality of life for these patients. BgRT is an innovative radiation technique that uses live data from positron emission tomography PET scans to precisely target active tumors during treatment. Participants receive a single fraction of BgRT at a dose of 14 gray on day 0. PETcomputed tomography CT scans are performed during the study and optionally during follow-up. The trial monitors patients over time to track pain response, toxicity, disease progression at treated sites, and rates of re-irradiation. During the study, patients undergo pain and quality of life assessments, imaging scans such as PETCT and MRI, and clinical evaluations at 2 weeks, 3 months, and then every 3 months up to one year. Researchers collect data on adverse events, patient-reported outcomes, and radiographic evidence to evaluate the treatments impact and safety over a year-long follow-up period.

Biology-Guided Radiation Therapy for the Treatment of Patients With Bone Metastases