Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies.
Layal Antoury, Ningyan Hu, Leonora Balaj...
https://pubmed.ncbi.nlm.nih.gov/30254196/Actively Recruiting
Age: 5Years +
All Genders
Healthy Volunteers
ID05019625
Developing Non-Invasive Tests to Measure Muscular Dystrophies Using Urine, Blood, Ultrasound, and Electrical Impedance
Led by Massachusetts General Hospital · Updated on 2025-11-24
465
Participants Needed
5
Research Sites
52 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying muscular dystrophies, including Myotonic Dystrophy, Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, and Facioscapulohumeral Muscular Dystrophy. The goal is to find less invasive ways to measure disease activity and severity compared to muscle biopsies, which are more invasive. This study focuses on evaluating whether urine and blood samples, along with painless tests like ultrasound and electrical impedance myography on arm and leg muscles, can help detect and assess these muscle diseases.
CONDITIONS
Brief Title
Biomarker Development for Muscular Dystrophies
Research Team
T
Tamkin Shahraki, MD
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