Actively Recruiting
Biomarker-Integrated Digital Guidance for Early Alzheimer's Detection (BRIDGE-AD): A Nationwide Multicenter Study
Led by Xuanwu Hospital, Beijing · Updated on 2025-12-16
6000
Participants Needed
6
Research Sites
19 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators propose a stepwise screening approach. The first step involves rapid digital pre-screening of cognitive function through three components: the SCD-9 questionnaire to capture subjective cognitive complaints, a digital cognitive assessment to evaluate objective performance, and a predictive model to estimate future dementia risk in cognitively normal individuals. The second step confirms the presence of AD pathology using blood-based biomarkers, with a head-to-head comparison of multiple novel candidates to identify those with the greatest diagnostic utility.
CONDITIONS
Official Title
Biomarker-Integrated Digital Guidance for Early Alzheimer's Detection (BRIDGE-AD): A Nationwide Multicenter Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 50 and above
- Living in the community for at least one year with established medical records
- No history of cognitive disorders such as mild cognitive impairment, dementia, or Alzheimer's disease
- Not currently using anti-dementia medications like cholinesterase inhibitors or memantine
- Willing to participate in the study
- The participant or their relatives can communicate normally in Chinese
- High-risk for dementia including complaints of cognitive decline, family history of AD in first-degree relatives, or known ApoE e4 carrier
You will not qualify if you...
- Presence of severe mental disorders such as bipolar disorder or schizophrenia
- Having any disease that makes it impossible to complete cognitive assessments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Xuanwu Hospital, Capital Medical University
Beijing, China
Actively Recruiting
2
Hainan Medical University
Hainan, China
Actively Recruiting
3
General Hospital of Ningxia Medical University
Ningxiang, China
Actively Recruiting
4
The First Hospital of China Medical Unversity
Shenyang, China
Actively Recruiting
5
Shenzhen Center For Chronic Disease Control
Shenzhen, China
Actively Recruiting
6
Yichun People'S Hospital
Yichun, China
Actively Recruiting
Research Team
Y
Yi Tang, M.D., Ph.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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