Actively Recruiting
Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Led by Aristotle University Of Thessaloniki · Updated on 2026-03-19
45
Participants Needed
1
Research Sites
246 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Diabetic ketoacidosis (DKA) is a severe metabolic complication in children with newly diagnosed type 1 diabetes mellitus (T1DM) and may be associated with early injury of vital organs such as the kidneys and the heart. Early detection of organ dysfunction is important for identifying children at increased risk for complications. This observational cross-sectional study aims to evaluate biomarkers of acute organ injury and associated clinical and echocardiographic parameters in children with newly diagnosed T1DM presenting with DKA, compared with children with newly diagnosed T1DM without DKA and healthy controls. Biomarkers including KIM-1, NGAL, high-sensitivity troponin, NT-proBNP, interleukin-6, and C-reactive protein will be measured during hospital admission and within the first 24-48 hours of hospitalization.
CONDITIONS
Official Title
Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 2 to 16 years
- Newly diagnosed type 1 diabetes mellitus
- Hospital admission for initial evaluation and treatment
- Presence or absence of diabetic ketoacidosis at diagnosis
- Written informed consent from parents or legal guardians
- Age-matched healthy children without diabetes (for control group)
You will not qualify if you...
- Previous diagnosis of diabetes mellitus
- Known chronic kidney disease
- Known cardiovascular disease
- Acute infection or inflammatory condition unrelated to diabetes
- Use of medications that may affect renal or cardiac biomarkers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hippokration General Hospital of Thessaloniki
Thessaloniki, Central Makedonia, Greece
Actively Recruiting
Research Team
A
Athina Stamati
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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