Biomarker Study in Adults After Out-of-Hospital Cardiac Arrest in the STEPCARE Trial

What this Trial Is About

Researchers are evaluating biomarkers in adult patients who have been treated in intensive care units after experiencing out-of-hospital cardiac arrest. This study is part of the Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation STEPCARE trial, which is a randomized trial exploring different sedation, temperature, and blood pressure targets in comatose patients after cardiac arrest. The substudy focuses on collecting and analyzing blood samples to understand outcomes better. Blood samples are collected at 12, 24, 48, and 72 hours after randomization at selected sites that participate in the biomarker substudy. These samples, including serum, plasma, and PAX-RNA vials, are processed and frozen on-site before being sent to a central biobank for batch analysis after the trial ends. Patients in this substudy have already been randomized in the main STEPCARE trial to different sedation, temperature, and blood pressure intervention groups. Participants will have their functional outcome assessed at 30 days and 6 months after cardiac arrest, with the primary outcome being poor functional outcome measured by the modified Rankin Scale at six months. Survival at 6 months and functional outcomes at 30 days are also measured. The study involves intensive care treatment and monitoring, with data collected during the hospital stay and follow-up assessments to evaluate recovery and survival over time.

Biomarkers After Out-of-hospital Cardiac Arrest- a STEPCARE Substudy