Actively Recruiting
Biomarkers in Autoimmune Diseases, Vasculitis and Auto Inflammatory Diseases
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-07-03
2250
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
I
Institut National de la Santé Et de la Recherche Médicale, France
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating autoimmune diseases, systemic vasculitis, and autoinflammatory diseases to find biomarkers in cytokines and lymphocytes that show disease activity. The goal is to develop follow-up markers that help personalize monitoring and treatment for each patient. These diseases affect the immune system with varying severity, and current treatments mainly control inflammation but often lead to relapses without clear ways to predict them. The study collects blood and tissue samples as part of regular patient care to analyze immunological data. Conducted at a specialized medical center certified for rare autoimmune and inflammatory diseases, this observational study focuses on advancing fundamental knowledge and identifying prognostic markers through blood tests. Participants include patients with various autoimmune and autoinflammatory diseases who will provide additional blood samples beyond routine care. Participants will undergo biological sample collection during their usual care visits, with researchers monitoring cytokine and lymphocyte profiles over approximately nine years. The study aims to correlate these immune profiles with disease activity, progression, clinical presentation, and relapse frequency. This long-term observation helps understand disease evolution and supports personalized care. Safety and usual medical care continue throughout the study period.
CONDITIONS
Brief Title
Biomarkers in Autoimmune Diseases, Vasculitis and Auto Inflammatory Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older
- Diagnosis of autoimmune systemic disease, systemic vasculitis, or autoinflammatory disease according to international criteria
- Includes conditions such as lupus, Sjögren syndrome, antiphospholipid syndrome, mixed connectivity, Sharp syndrome, scleroderma, myositis
- Includes vasculitis of large, small, and medium vessels such as giant cell arteritis, Takayasu arteritis, Behçet disease, ANCA vasculitis, cryoglobulinemic vasculitis, IgA vasculitis
- Includes Buerger's disease, granulomatosis, sarcoidosis, uveitis
- Includes monogenic and polygenic autoinflammatory diseases such as family Mediterranean fever, TRAPS, CAPS, chronic atrophic polychondritis, pericarditis
- Includes recurrent fevers and unexplained inflammatory syndromes
- Includes inflammatory amyloidosis
- Patients must be affiliated with French social security
You will not qualify if you...
- Persons deprived of liberty by judicial or administrative decision
- Persons receiving psychiatric care without their consent
- Adults under legal protection measures such as guardianship or curatorship
- Persons unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 9 years
Participants are observed over time with blood samples collected in addition to routine care to study biomarkers related to autoimmune diseases, vasculitis, and autoinflammatory diseases.
Blood collections alongside routine care visits as scheduled by healthcare providers
Trial Site Locations
Total: 1 location
1
Département de Médecine Interne et Immunologie Clinique (DMIIC), Hôpital Pitié-Salpêtrière
Paris, France, France, 75013
Actively Recruiting
Research Team
D
David Saadoun, Professor
N
Nassima Mansour
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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