Actively Recruiting
Biomarkers of Brain Injury in Children With Primary Brain Tumors Observational Study
Led by Uppsala University · Updated on 2026-02-02
560
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
Uppsala University
Lead Sponsor
R
Region Blekinge
Collaborating Sponsor
AI-Summary
What this Trial Is About
This observational study focuses on children aged 0 to 17 years with primary brain tumors. Researchers aim to identify sensitive plasma biomarkers that indicate brain injury caused by different cancer treatments such as surgery, chemotherapy, and radiation. They will compare biomarker levels between children receiving radiation, those who do not receive radiation, and healthy children without brain tumors to understand treatment-specific effects better. Participants are divided into three groups: those treated with surgery and radiation therapy, those treated with surgery and other cancer treatments but no radiation, and healthy controls. Blood plasma samples are collected at multiple time points including before surgery, shortly after surgery, and at intervals up to 36 months post-surgery. Children receiving radiation will also provide samples every two weeks during treatment, and samples may be collected before starting other treatments like chemotherapy. Healthy controls provide one plasma sample. Throughout the study, participants undergo blood sample collection to monitor biomarkers of brain injury over time, up to three years after treatment begins. Researchers will analyze these samples to track changes related to treatment effects. The study includes ongoing monitoring without intervention, and participation involves regular follow-ups and sample donations to support understanding of brain injury in pediatric brain tumor patients.
CONDITIONS
Brief Title
Biomarkers of Brain Injury in Children With Brain Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 0 to 17 years old
- Diagnosed with primary brain tumor through surgery, biopsy, or other diagnostic methods
- Referred for radiotherapy and/or other cancer treatments (for radiation group)
- Not referred for radiotherapy but treated with other cancer treatments or radiation-naive (for non-radiation group)
- Healthy children aged 0 to 17 years old (healthy control group)
You will not qualify if you...
- Tumor only in the spinal cord (solitary spinal tumor) for groups A and B
- Tumor considered palliative at diagnosis (e.g., diffuse intrinsic pontine glioma) for groups A and B
- Diagnosis of chronic disease requiring continuous medication for healthy control group
- Unable to provide informed consent due to language difficulties for all groups
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 month
Participants undergo diagnostic procedures to confirm brain tumor status or healthy control status.
1 to 2 visits depending on diagnostic needs
Duration - Up to 3 years
Participants are observed for biomarkers of brain injury from enrollment until up to 3 years after start of primary treatment or observation.
Periodic visits according to treatment and follow-up schedules
Trial Site Locations
Total: 1 location
1
Uppsala University
Uppsala, Sweden
Actively Recruiting
Research Team
C
Christoffer Ehrstedt, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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