Study of Protein Biomarkers in Cervical Mucus to Detect Endometrial Receptivity in Women Undergoing Fresh or Frozen Embryo Transfer for Infertility Treatment

What this Trial Is About

Researchers are investigating proteins in cervical mucus to find new biomarkers that could indicate when the lining of the uterus endometrium is receptive to embryo implantation. This study focuses on women undergoing infertility treatments such as fresh or frozen embryo transfers. The goal is to improve the understanding of endometrial receptivity, which is crucial for successful implantation but is currently difficult to assess due to a lack of reliable markers. Participants are divided into two groups those undergoing cycles with fresh embryo transfers and those with frozen embryo transfers. Cervical mucus samples will be collected during these treatment cycles and analyzed using a highly sensitive mass spectrometer to detect protein patterns. The study aims to compare protein profiles between patients who become pregnant and those who do not, seeking new biomarkers to guide clinical decisions. During the study, participants will have cervical mucus collected as part of their infertility treatment cycles. Researchers will analyze these samples over a period of 48 months to identify protein differences related to pregnancy outcomes. The study will monitor and compare protein spectra to detect new markers of endometrial receptivity. This research could help improve timing and success rates of embryo transfers in the future.

Biomarkers of Endometrial Receptivity