Actively Recruiting
Biomarkers to Enhance Early Schizophrenia Treatment
Led by Northwell Health · Updated on 2026-04-27
180
Participants Needed
2
Research Sites
252 weeks
Total Duration
On this page
Sponsors
N
Northwell Health
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is recruiting participants who are experiencing a first episode of psychosis and who have certain genetic factors that may make them respond better to certain medications that are used to treat people with psychosis.
CONDITIONS
Official Title
Biomarkers to Enhance Early Schizophrenia Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 35
- Diagnosed with schizophrenia, schizoaffective disorder, or schizophreniform disorder by SCID5
- Current positive symptoms rated moderate or higher on BPRS positive subscale items
- Preserved striatal connectivity shown by MRI scan
- No high-risk MC4R genotype based on genetic testing
- No high-risk HLA-DQB1 genotype based on genetic testing
- Early phase of illness with 4 weeks or less cumulative lifetime antipsychotic use
- Ability to provide informed consent
You will not qualify if you...
- Serious neurological or endocrine disorder affecting study results
- Abnormal EKG interfering with study results
- Medical condition needing psychotropic medication treatment
- Significant risk of suicidal or homicidal behavior
- Cognitive limitations or inability to provide informed consent
- Contraindications to MRI such as pacemaker
- Moderate or severe substance use disorder within 3 months except nicotine
- Mild substance use disorder for certain substances within 3 months or positive drug screen
- Suspected intellectual disability with IQ score below 71
- Prior psychosurgery
- Pregnancy
- Seizure disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Feinstein Institute for Medical Research
Glen Oaks, New York, United States, 11004
Actively Recruiting
2
Centre for Addiction and Mental Health
Toronto, Canada
Actively Recruiting
Research Team
P
Patricia Marcy
CONTACT
C
Cristina Gonzalez
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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