Actively Recruiting
Biomarkers for Monitoring Dementia Progression
Led by IRCCS San Raffaele Roma · Updated on 2025-03-03
300
Participants Needed
2
Research Sites
136 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The variable course of Alzheimer's disease (AD) and the paucity of adequate cures urges to implement new strategies for its early detection and clinical intervention. Studying the etiopathogenesis and pathophysiological mechanisms of AD is a necessary prerequisite for the development of new biomarkers and innovative therapies. Contrarily to anatomical structures, cortical connectivity networks are already deteriorated in early AD and could be a reliable marker of early cognitive decline. Our aim is to characterize the neurophysiological parameters in mild AD, in patients with mild cognitive impairment and in matched healthy subjects to identify discriminating criteria. Concurrently, the study of AD onset and progression in a mouse model, will allow evaluating the causal effect of inflammation on disease progression and to develop a new class of biomimetic anti-inflammatory nanoparticles formulated to have the intrinsic ability to induce brain's activated microglia to an M2 phenotype.
CONDITIONS
Official Title
Biomarkers for Monitoring Dementia Progression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of mild Alzheimer's disease or mild cognitive impairment (MCI)
You will not qualify if you...
- Major psychosis, genetic, metabolic, or other neurological disorders
- Acute or chronic medical illness that is not well compensated
- Any medical or drug-related condition affecting cognitive or mood status
- History or current alcohol or illicit drug abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
IRCCS San Raffaele
Roma, Italy, 00163
Active, Not Recruiting
2
Azienda Ospedaliero-Universitaria di Sassari
Sassari, Italy, 07100
Actively Recruiting
Research Team
L
Lucia Gatta, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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