Actively Recruiting
Biomarkers in Patients With Anemia-Induced Thrombocytopenic Bleeding
Led by Donald Arnold · Updated on 2025-04-27
60
Participants Needed
1
Research Sites
81 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This pilot study aims to gather preliminary evidence on how different hemoglobin levels impact blood biomarkers related to bleeding. The feasibility of conducting a future larger clinical trial will also be assessed. Red blood cell transfusions are part of the standard of care for patients with leukemia. This study evaluates two transfusion strategies: one that maintains hemoglobin levels above the standard-of-care threshold, reflecting current routine practice; and another that maintains hemoglobin levels above 110 g/L, which is closer to the normal hemoglobin range. The normal hemoglobin range is 120-160 g/L for females and 140-180 g/L for males. Raising hemoglobin levels closer to normal values may reduce bleeding risk.
CONDITIONS
Official Title
Biomarkers in Patients With Anemia-Induced Thrombocytopenic Bleeding
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old or older
- Currently an inpatient
- Diagnosed with acute myeloid leukemia or acute lymphocytic leukemia
- Started induction chemotherapy less than 5 days ago
- Hemoglobin level under 130 g/L at enrollment
You will not qualify if you...
- Unable or unwilling to provide informed consent
- Unwilling to receive blood transfusions
- Life expectancy less than 72 hours
- Receiving palliative chemotherapy
- Requires specialized blood products (e.g., antigen-matched, irradiation)
- Diagnosed with acute promyelocytic leukemia
- Diagnosed with hyperleukocytosis (white blood cell count over 100 x 10^9/L)
- Diagnosed with coagulopathies or currently treated with therapeutic anticoagulants, aspirin, or nonsteroidal anti-inflammatory drugs
- Evidence of iron overload (ferritin over 800 ng/mL, transferrin saturation over 80%)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Juravinski Hospital
Hamilton, Ontario, Canada, L8V 1C3
Actively Recruiting
Research Team
D
Dimpy Modi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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