Actively Recruiting
Biomarkers of Phage Treatment Response in NTM and Other Infections
Led by NYU Langone Health · Updated on 2025-10-30
100
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to identify biomarkers associated with response to phage therapy for refractory bacterial infections. This includes mycobacteriophage treatment for patients with nontuberculous mycobacterial infections. Blood and airway samples will be obtained from follow up visits of patients with refractory bacterial infections that are considered for phage therapy. Samples will be compared between those that receive phage therapy and those that did not. Biomarkers will include changes in the airway microbiome, transcriptome, inflammatory cytokines, and development of neutralizing antibody against phages. The primary endpoint is to identify biomarkers associated with clinical and/or radiographic improvement and/or culture improvement which includes clearing of cultures or decrease in qualitative or resolution of signs and symptoms of infection after at least 6-8 weeks of bacteriophage therapy.
CONDITIONS
Official Title
Biomarkers of Phage Treatment Response in NTM and Other Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years of age or older
- Provide written consent
- Willing and able to participate in study procedures
- Diagnosis of bacterial or mycobacterial infection meeting clinical, radiographic, and microbiologic criteria for treatment
- Being considered by a clinician for phage therapy as part of standard care
You will not qualify if you...
- Under 18 years of age
- Pregnant individuals due to unknown risks of phage treatment
- Breastfeeding individuals due to unknown risk to the infant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
Research Team
D
Doreen Addrizzo-Harris, MD, FCCP
CONTACT
L
Lira Gutierrez
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here