Actively Recruiting
Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer
Led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Updated on 2025-03-30
152
Participants Needed
2
Research Sites
469 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Neoadjuvant therapy has been widely applied to locally advanced rectal cancer. However, about 50% of patients receiving this therapy do not respond well as evidenced by the fact that their T or N stages are not effectively decreased judged by postoperative pathological examination. The purpose of this trail is to identify the biomarkers (from within patients' tumor mass before neoadjuvant therapy) to predict resistance to neoadjuvant therapy. These biomarkers can help stratify neoadjuvant-resistant patients towards surgery while avoiding unnecessary chemoradio-based neoadjuvant therapy.
CONDITIONS
Official Title
Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histopathology proved to be adenocarcinoma of the rectum.
- Tumor edge is within 12 cm of the anus margin.
- Cancer stage is T3-T4, N0 or any T, N1-2 according to the eighth edition AJCC TNM.
- No prior chemotherapy, radiotherapy, or immunotherapy before neoadjuvant therapy.
- Understands and agrees to sign informed consent for the study.
You will not qualify if you...
- Presence of intestinal obstruction, impending obstruction, or perforation.
- Diagnosis of other malignancies within the past 5 years.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Wuhan Union Hospital
Wuhan, Hubei, China, 430022
Actively Recruiting
2
Hubei Cancer Hospital
Wuhan, Hubei, China, 430079
Not Yet Recruiting
Research Team
Z
Zheng Wang, MD/PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here