Actively Recruiting
Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH)
Led by NHS Greater Glasgow and Clyde · Updated on 2024-07-03
750
Participants Needed
1
Research Sites
142 weeks
Total Duration
On this page
Sponsors
N
NHS Greater Glasgow and Clyde
Lead Sponsor
U
University of Glasgow
Collaborating Sponsor
AI-Summary
What this Trial Is About
Genetic cardiomyopathy is increasingly recognised and can lead to heart failure, arrhythmia and sudden cardiac death. Some gene positive patients have rapidly progressive disease with high rates of heart failure and cardiac transplantation, while others present with SCD. Other gene positive patients will never develop cardiomyopathy. At present, we cannot distinguish between these groups and rely on expensive and labour-intensive surveillance by electrocardiography, echocardiography and sometimes cardiac magnetic resonance imaging. This study will investigate existing and novel biomarkers (including blood, urine electrocardiographic and imaging) at various stages of disease in patients with a personal or family history of TTN, MYBPC3, LMNA, FLNC or DSP gene variant, which are known to cause cardiomyopathy.
CONDITIONS
Official Title
Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 10 years of age or older
- Written informed consent or assent
- Pathogenic or likely pathogenic variant in a cardiomyopathy gene (TTN, LMNA, MYBPC3, DSP, FLNC) or undergoing predictive genetic testing (negative results invited to control arm)
You will not qualify if you...
- Unable to consent
- Geographical or social reasons preventing attendance at study center
- Unable to complete study assessments
- Severe non-cardiac disease expected to reduce life expectancy to less than 5 years
- Current participation in a blinded drug interventional trial or treatment within 4 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Queen Elizabeth University Hospital
Glasgow, United Kingdom, G51 4TF
Actively Recruiting
Research Team
C
Caroline J Coats, MBBS, PhD
CONTACT
R
Rachel C Myles, MBBS, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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