Study of Early Brain Biomarkers and Cognitive Development in Infants Aged 3 to 24 Months With Prior Neonatal Brain Injury or Healthy Infants

What this Trial Is About

This research focuses on the long-term cognitive development of children, including both healthy infants and those who experienced a perinatal brain injury such as hypoxic-ischemic encephalopathy, cerebral palsy, or premature birth. The study aims to predict executive dysfunction and cognitive outcomes by assessing differences between children with prior brain injuries and healthy controls. It is an observational study sponsored by the University of Wisconsin, Madison. Children aged 3 to 24 months, including those diagnosed with perinatal brain injuries and healthy infants without neurological history, participate in this study. Participants complete in-person games and assessments at the University Hospital, including EEG evaluations measuring brain activity in delta and theta bands. The study includes repeated assessments at 6, 12, and 18 months to track development. During the study, children engage in cognitive tasks such as the Infant Attention Task and the A not B Task. Parents also complete questionnaires about their childs behavior, stress levels, and daily hassles. Researchers monitor outcomes through standardized tests like the Bayley Assessment and various parenting stress scales. Data collection occurs at multiple time points over an 18-month period to understand developmental changes and factors influencing cognitive outcomes.

Biomarkers Study in Infants With Prior Neonatal Brain Injury