Actively Recruiting

Phase Not Applicable
Age: 18Years - 75Years
All Genders
Healthy Volunteers
ID06260813

Biomechanical and Morphological Characterization of the Foot in Patients With Posterior Tibial Tendon Dysfunction

Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2025-04-15

100

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Posterior tibial tendon dysfunction (PTTD) is a progressive condition affecting the tendon of the tibialis posterior muscle, leading to symptoms like tendinopathy or rupture. It causes difficulty in locking the mid foot and is a major contributor to adult acquired flatfoot deformity, which can result in severe pain, walking difficulties, foot arch collapse, and joint damage. Current treatment decisions rely on classifications based on pain, foot joint flexibility, tendon condition via ultrasound, and arthritic changes on X-rays, but do not consider foot bone shape or biomechanical function. This research studies the biomechanical and morphological features of the foot in PTTD patients by combining standard clinical assessments with advanced gait analysis and imaging. Participants include 75 PTTD patients across stages I to III and 25 healthy volunteers. The study uses X-rays, ultrasound, MRI, CT scans, and a sophisticated gait analysis lab with a 3D camera system, force plate, and pressure platform to measure kinematics and kinetics of foot joints, focusing especially on the mid foot segment often neglected in previous research. Participants will undergo these diagnostic tests and gait analyses to collect data on joint motion, loading, and bone shape. Researchers will measure kinematic characteristics, center of pressure, angular velocity, joint moments, power absorption and generation, as well as bone morphology over one year. Secondary assessments include foot and ankle functional scores, quality of life surveys, and pain and satisfaction scales. This detailed evaluation aims to improve classification and guide personalized treatment for PTTD patients.

CONDITIONS

Brief Title

Biomechanical and Morphological Characterization of PTTD

Who Can Participate

Age: 18Years - 75Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Posterior tibial tendon dysfunction of any clinical stage
  • Age between 18 and 75 years
  • Signed informed consent form (ICF) obtained
  • For control group: no foot pain or foot and ankle pathology such as pes plano valgus or pes cavo varus
  • Control group age between 18 and 75 years
  • Control group signed informed consent form (ICF) obtained
Not Eligible

You will not qualify if you...

  • Younger than 18 years
  • Unable to walk without mobility aids
  • Unable to walk less than 100 meters
  • Leg length difference greater than 3 cm
  • Body mass index (BMI) above 30 kg/m²
  • Unable to perform gait analysis
  • Any medical condition affecting normal gait
  • Pregnancy at the start or during the study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Up to 1 day

Participants undergo diagnostic tests including X-rays, ultrasound, MRI, CT-scan, and gait analysis to assess biomechanical and morphological characteristics of the foot and ankle.

1 visit (in-person)

Long-term Monitoring

Duration - 1 year

Participants are monitored over time to assess kinematic, kinetic, and morphological outcomes related to posterior tibial tendon dysfunction.

Follow-up assessments periodically during the year

Trial Site Locations

Total: 1 location

1

UZ Leuven

Leuven, Vlaams-Brabant, Belgium, 3000

Actively Recruiting

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Research Team

S

Sander Wuite

K

Kevin Deschamps

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

2

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