Investigating the Biomechanical and Functional Outcomes of Autologous Chondrocyte Implantation for Knee Cartilage Injuries: A Multi-centre Study

What this Trial Is About

Knee cartilage injuries can cause pain and limit movement, affecting daily activities like walking and sports. Since cartilage heals poorly on its own, surgery such as autologous chondrocyte implantation (ACI) is often needed. This study aims to understand how knee function changes after ACI surgery, helping doctors and patients know what to expect and identify issues that physiotherapy might improve. The research is important because untreated cartilage damage can lead to arthritis, a painful condition later in life. Participants in this study will all undergo ACI surgery, which involves two procedures: first, harvesting cartilage cells from the patient, then growing these cells in a lab before implanting them to repair the knee's damaged cartilage. The study will take place at seven hospitals, with patients invited to attend two appointments at their hospital—one before surgery and one six months after—to assess knee function. During these visits, researchers will measure knee range of motion using a goniometer and analyze walking patterns using motion capture technology. They will also evaluate balance and walking ability. The study's results will provide detailed information about knee movement and function after ACI surgery, which could help improve patient care and treatment outcomes. The entire participation spans about six months with assessments before and after surgery.

The Biomechanical Outcomes of Autologous Chondrocyte Implantation