Actively Recruiting
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
Led by Massachusetts General Hospital · Updated on 2025-12-09
3000
Participants Needed
1
Research Sites
599 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
R
Roche Diagnostics GmbH
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may develop and progress over time. We will evaluate distinct sub-groups of heart failure (also known as heart failure phenotypes) and cardiomyopathies including amyloidosis with an ultimate goal of bringing the right medications and therapy to the right patients to optimize benefit and minimized side effects, an effort to improve precision medicine in heart failure.
CONDITIONS
Official Title
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years and older
- History of clinical symptoms consistent with heart failure
- At least one supporting evidence of heart failure such as:
- NT-proBNP > 125 pg/mL
- BNP > 35 pg/mL
- Capillary wedge pressure ≥ 15 mmHg on right heart catheterization or cardiac index <2.8 L/min/m2
- Left ventricular end-diastolic pressure (LVEDP) ≥ 15 mmHg
- Radiographic evidence of pulmonary edema
- Improvement in symptoms with diuretic initiation or increase
- Cardiopulmonary exercise testing (CPET) showing cardiac cause of symptoms
- Heart failure with preserved ejection fraction (LVEF ≥ 50%) or reduced ejection fraction (LVEF < 50%)
You will not qualify if you...
- End stage renal disease on dialysis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
A
Abbie Macher, BS
CONTACT
L
Laura Stockhausen, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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