Actively Recruiting
Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-03-12
80
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to study the way radioembolization works by collecting biopsy samples of participants' tumors after the procedure. This research may improve the way that radioembolization is performed, which could help people whose cancer has spread to the liver. The research may also provide information about how tumors respond to radioembolization.
CONDITIONS
Official Title
Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Histologically confirmed primary adenocarcinoma of the colon or rectum
- Liver metastases considered unresectable or not suitable for percutaneous ablation
- Existing biopsy tissue samples from target tumor within 42 days prior to treatment or clinical indication for biopsy at treatment
- Adequate blood cell counts (WBC > 1.5 x 10^9/L, platelet count > 50 x 10^9/L)
- Adequate kidney function (creatinine < 1.5 mg/dL)
- Total bilirubin level ≤ 1.5 mg/dL
- For radiation segmentectomy: patients not eligible for surgery or thermal ablation
You will not qualify if you...
- Prior hepatic radiotherapy to the lesion or lobe being treated
- Severe cirrhosis
- Severe portal hypertension
- Uncorrectable blood flow to gastrointestinal tract
- Radiation absorbed dose to lungs >30 Gy (or >50 Gy in multiple sessions)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
Research Team
C
Constantinos T Sofocleous, MD, PhD
CONTACT
A
Assen Kirov, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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