Actively Recruiting
A Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-Up
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2025-12-02
10000
Participants Needed
1
Research Sites
1083 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Allergic or sinus diseases can affect the skin, sinuses, airways, and other parts of the body. Examples include pollen and environmental allergies, food allergies, asthma, and eczema. To learn more about how to prevent and treat these diseases, researchers need to study data, blood, fluid, and tissue samples from people affected by them. Objective: To collect data, blood, fluid, and tissue samples from people with allergic or sinus diseases. Eligibility: People aged 3 to 100 years with allergic or sinus diseases. Design: Participants will have at least one clinic visit, and most participants will have a baseline visit, annual visit, and an end of study visit. The duration of the study is 1 to 3 years. During the first clinic visit, the following procedures will be done to collect data, blood, fluid, and tissue samples: * Blood will be collected. * Cells and fluid may be collected from the inside of the nose using a long swab, and a small piece of skin may be scraped from inside the nose. * Skin cells will be collected by rubbing with a cotton swab. * A urine sample will be collected. * Allergy skin prick tests. Allergy-causing substances will be placed on the back or arm and the skin underneath gently scratched. If the participant is allergic to the substance, the skin may become red, itchy, and swollen locally ( at the site of the test). * Lung function test. Participants will breathe into a machine that measures the air moving in and out of their lungs. * If, as part of their routine care, participants are undergoing procedures such as having nasal polyps removed, skin tissue samples taken, or gastrointestinal biopsies, additional tissues may be collected for this study. * Participants will complete online questionnaires regarding their symptoms, health, and life. Participants may return for more visits for up to 3 years.
CONDITIONS
Official Title
A Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-Up
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 3 to 100 years
- Suspected or confirmed allergic, atopic, respiratory, or nasal/sinus disorder, or history of an immune dysregulatory disorder
- Or clinical history of immediate hypersensitivity reaction to aeroallergens, food, insect stings, or medications
- Able to provide informed consent
- Have or willing to obtain a non-NIH primary physician to manage health and emergencies
- Willing to allow storage of blood, skin swabs, nasal fluid/brushings, bodily fluids, and other tissue samples for future medical research
You will not qualify if you...
- Any physical or psychological condition that the investigator feels prevents participation
- For additional skin biopsies: history of keloid formation, under 18 years old, or pregnant
- For additional nasal-sinus polyp biopsies: on blood thinners unless stopped, under 18 years old, or pregnant
- For allergy skin prick testing: pregnant participants
- For endoscopic biopsy: uncontrolled asthma, serious anesthesia reactions, low hemoglobin or platelets, pregnant or breastfeeding, severe lung disease, recent abdominal surgery, anticoagulant therapy that cannot be stopped, or under 18 years old
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
H
Hye Jeong C Bolan, R.N.
CONTACT
P
Paneez Khoury, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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