Study of Immune Changes in Patients Ages 12 to 99 Undergoing Plasma Exchange for Antibody-Mediated Diseases

What this Trial Is About

Researchers are studying patients with immune-mediated diseases who undergo plasma exchange PLEX procedures to remove harmful substances, often antibodies. This study aims to collect and preserve blood samples from these patients to analyze antibody levels and immune factors over time. The goal is to better understand how plasma exchange affects normal and harmful immune components in various patients. Participants will continue their usual plasma exchange treatments without changes from the study. The study groups include patients receiving plasma as a replacement fluid and those receiving saline or 5% albumin. Blood samples such as plasma, serum, and immune cells PBMCs will be collected at multiple points during and after treatment to facilitate current and future research. During the study, participants will provide blood samples and clinical data over the treatment course, typically lasting 1-2 weeks, to track antibody levels and immune factors. The study will also follow patients after plasma exchange completion to collect additional samples. This long-term collection helps researchers monitor immune changes and supports future studies. Participation involves no alteration to treatment plans and continues until the end of the plasma exchange course.

Biorepository and Registry for Plasma Exchange Patients