Actively Recruiting
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
Led by TScan Therapeutics, Inc. · Updated on 2025-11-24
300
Participants Needed
12
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation. These tissues contain both cytotoxic and helper T cells that are driving their disease, and these T cells are being guided by TCRs that recognize tissue-specific targets. By collecting tissue when a patient has active inflammation, it is possible to determine which T cells are activated and undergoing clonal expansion in the patient's diseased organ. TScan has developed a genome-wide, high-throughput technology to determine the natural, physiological target of any TCR (Kula, 2019). The goal of this study is to isolate T cells from inflamed tissues and matched blood samples and/or matched normal tissues (for patients with inflammatory bowel diseases). T cell clones that are expanded in diseased tissues relative to blood or normal tissues will be selected and the targets of their TCRs will be defined using TScan's genome-wide, high-throughput target ID technology. The goal of this study is to discover a collection of peptide targets, along with their associated TCRs to be developed as new tolerogenic therapies for patients with autoimmune diseases.
CONDITIONS
Official Title
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at the time of informed consent
- Known or suspected diagnosis of autoimmune diseases including Crohn's disease, ulcerative colitis, celiac disease, ankylosing spondylitis, non-radiographic axial spondyloarthritis, multiple sclerosis, scleroderma, systemic sclerosis with pulmonary involvement, other autoimmune diseases, or apparent evolving autoimmune disease
- Receiving disease-modifying treatments not known to be directly toxic to T cells
- Candidate for biopsy or tissue sample collection during a clinically indicated or research procedure
- Ability to understand and willingness to sign informed consent when required
You will not qualify if you...
- Treatment with drugs known to be T cell toxic that cannot be stopped for 4 weeks or longer, including glucocorticoids, sulfasalazine, aminosalicylates, thiopurines, systemic JAK inhibitors, CD52 inhibitors, methotrexate, cladribine, or teriflunomide
- Any serious medical or psychiatric condition that could interfere with safety or consent
- Dementia, altered mental status, or psychiatric conditions preventing informed consent
- History of severe allergic reaction to local anesthetics or sedation medications if required for biopsy procedures
- Pregnant or nursing women
- Any other condition judged by the treating clinician to make study participation unreasonably hazardous
AI-Screening
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Trial Site Locations
Total: 12 locations
1
Knowledge Research Center
Orange, California, United States, 92868
Actively Recruiting
2
Cura Clinical Research
Sherman Oaks, California, United States, 91403
Actively Recruiting
3
Arnold Arthritis & Rheumatology
Skokie, Illinois, United States, 60076
Actively Recruiting
4
University of Kentucky Research Foundation
Lexington, Kentucky, United States, 40536
Actively Recruiting
5
Massachusetts Eye Research and Surgery Institution (MERSI)
Waltham, Massachusetts, United States, 02451
Actively Recruiting
6
Susquehanna Research Group
Harrisburg, Pennsylvania, United States, 17110
Actively Recruiting
7
Nexus Research
Cranston, Rhode Island, United States, 02920
Actively Recruiting
8
Nexus Research
Cranston, Rhode Island, United States, 02920
Actively Recruiting
9
RI Rheumatology
Cranston, Rhode Island, United States, 02920
Actively Recruiting
10
Palmetto Gastroenterology Clinical Research, LLC
Summerville, South Carolina, United States, 29486
Actively Recruiting
11
Novel Research
Bellaire, Texas, United States, 77401
Actively Recruiting
12
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Completed
Research Team
L
Laurie Barefoot
CONTACT
S
Shrikanta Chattopadhyay
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
9
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