Collection and Banking of Blood and Tissue Samples from Adults With Cancer or Premalignant Conditions for Immunotherapy Research

What this Trial Is About

Cancer poses a significant health challenge worldwide, with over 1.5 million new cases diagnosed annually in the United States. Researchers aim to better understand the biology of various cancers and premalignant conditions, as well as why certain cancers respond differently to treatments. This observational study focuses on collecting samples from adults diagnosed with cancer or premalignant conditions to support research in immunotherapy and related biological studies. Participants will provide biospecimens such as blood, tumor tissue, bone marrow, urine, skin, and other body fluids. Some may undergo procedures like apheresis, bone marrow biopsy, or imaging scans CT, MRI, PET, ultrasound to help locate tumors. Samples will be used for banking and laboratory research without receiving experimental treatments. Re-enrollment is allowed for a small number of participants. During the study, participants will have medical histories, physical exams, and blood and urine tests at least once. Additional procedures may occur multiple times depending on the study need. Researchers will contact participants by phone yearly to monitor their health. The primary outcome is ongoing sample acquisition, with secondary measures including associations between clinical data and biospecimen characteristics. The study may continue until December 2032.

Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols