Actively Recruiting
Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols
Led by National Cancer Institute (NCI) · Updated on 2026-06-05
500
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying biospecimens from adults with cancer, premalignant conditions, or immunodeficiencies that increase cancer risk to better understand why different cancers respond differently to treatment. The goal is to support immunotherapy research by analyzing biological samples and clinical data. This observational study is sponsored by the National Cancer Institute and aims to collect various samples for ongoing research. Participants will provide samples such as blood, apheresis products, tumor tissue, body fluids, bone marrow, skin, and mucosa for banking and laboratory studies. No experimental treatments will be given as part of this protocol. Some participants may undergo procedures like apheresis and bone marrow biopsy. Re-enrollment is allowed for a few participants. During the study, participants will have medical history reviews, physical exams, and blood and urine tests at least once. Imaging scans such as CT, MRI, PET, or ultrasound may be done to locate tumors. Participants will be contacted annually by phone to check on their health status. The study monitors ongoing sample acquisition and examines relationships between clinical factors, biospecimen features, and patient demographics. The trial may last until December 2032.
CONDITIONS
Brief Title
Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of cancer, premalignant condition, or immunodeficiency increasing cancer risk
- Age 18 years or older
- ECOG performance status between 0 and 3
- Ability and willingness to provide informed consent
- For apheresis participants: hemoglobin ≥ 8 mg/dL, platelet count > 75 K/microL, weight ≥ 48 kg, and adequate venous access
You will not qualify if you...
- Active medical or psychological illnesses that increase risk
- Inability to provide informed consent
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Ongoing throughout participation
Participants provide various biospecimens such as blood, apheresis products, tumor tissue, body fluids, and others for banking and research studies.
Visits as needed for biospecimen collection
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Scott M Norberg, D.O.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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