Actively Recruiting
Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols
Led by National Cancer Institute (NCI) · Updated on 2026-04-29
500
Participants Needed
1
Research Sites
868 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Cancer has a major impact in the United States and across the world. In 2015, over 1.5 million new cases of cancer were diagnosed in the U.S. Researchers want to study samples from people with cancer or a pre-malignant condition. They hope to develop more effective treatments. Objective: To better understand the biology of malignancies and why certain cancers respond differently to treatment. Eligibility: Adults at least 18 years old with cancer or a pre-cancerous condition. Design: Participants will be screened with a medical history, physical exam, and blood tests. Their diagnosis will be confirmed by the NCI Laboratory of Pathology. Participants will send tissue blocks or slides from their original tumor biopsy. At least once, participants will have a medical history, physical exam, and blood and urine tests. Participants may have the following tests. They may have them more than once: Apheresis. A needle in one arm removes blood. Blood is run through a machine and the sample cells are taken out. The rest of the blood is returned by a needle in the other arm. Bone marrow aspiration and biopsy. The hipbone will be numbed. A needle will be put into the hipbone. Bone marrow will be taken out through the needle. Piece of cancer tissue taken by a needle and syringe. Computed tomography (CT) scan, magnetic resonance imaging (MRI) and/or positron emission tomography (PET) scan or ultrasound to help locate their tumor. For the scans, they lie in a machine that takes pictures. A small piece of skin removed. Participants will be contacted by phone once a year to find out how they are doing.
CONDITIONS
Official Title
Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of cancer, a premalignant or neoplastic condition, or disease increasing cancer risk
- Age 18 years or older
- ECOG performance status of 0 to 3
- Ability and willingness to provide informed consent
- For apheresis participants: hemoglobin ≥ 8 mg/dL and platelet count > 75 K/microL
- For apheresis participants: weight ≥ 48 kg
- For apheresis participants: central line in place or adequate venous access
You will not qualify if you...
- Active medical or psychological illnesses that increase risk to the participant
- Inability to provide informed consent
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Scott M Norberg, D.O.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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