Comprehensive genomic characterization of head and neck squamous cell carcinomas.
Cancer Genome Atlas Network
https://pubmed.ncbi.nlm.nih.gov/25631445Actively Recruiting
Age: 3Years - 120Years
All Genders
ID03429036
Biospecimen Procurement for the Study of Head and Neck Disorders
Led by National Cancer Institute (NCI) · Updated on 2026-04-29
1000
Participants Needed
9
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating disorders affecting the head and neck to improve understanding and aid in developing better treatments. This observational study aims to create a biorepository of both diseased and normal tissue samples from individuals with head and neck conditions. The research is conducted by the National Cancer Institute and focuses on collecting valuable biological materials for future studies related to these disorders. Participants diagnosed with head and neck conditions can contribute by allowing leftover tissue samples from their clinical care or previous research to be stored for study. The study has two parts: Part 1 involves sharing surgical waste specimens for research, while Part 2 includes additional sample collection such as blood draws, cheek swabs, saliva collection, and, for adults 18 and older, optional skin or mucosal biopsies. No experimental treatments are given during this study. During the study, participants will undergo screening including questionnaires, medical history review, and physical exams. Samples collected will be used for genetic and molecular research. The primary outcome is to establish a repository of tissue specimens by December 2026. Participant involvement may include providing permission for sample use, additional sample collection, and ongoing sharing of specimens for approved research projects. The study continues to share samples for cellular and genetic analysis to support future research on head and neck disorders.
CONDITIONS
Brief Title
Biospecimen Procurement for Head and Neck Disorders
Who Can Participate
Age: 3Years - 120Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age 3 and older
- Able to provide own consent or have a parent/guardian consent for minors
- Diagnosed with a head or neck condition requiring tissue removal for clinical care or research
- Willingness and ability to sign informed consent
You will not qualify if you...
- Unwilling to share leftover tissue specimens for research (Part 1)
- Active major organ disorders increasing biopsy risk, such as bleeding disorders or severe heart and lung conditions (Part 2)
- Medical conditions increasing risk from biopsies or blood draws (Part 2)
- Participants under 18 years are excluded from oral mucosal and skin biopsies (Part 2)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Sample Collection
Duration - Varies depending on surgical schedule and specimen availability
Participants share leftover tissue specimens from surgical procedures and may provide additional biospecimens such as blood, saliva, oral swabs, or biopsies depending on age and eligibility.
1 or more visits depending on surgical procedures and additional biospecimen collection
Long-term Monitoring
Duration - Up to study completion in 2026
Participants may be followed for ongoing specimen collection and research use of biospecimens in approved studies.
Additional visits as needed depending on research requirements
Trial Site Locations
Total: 9 locations
1
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
2
Johns Hopkins Hospital Sibley Memorial Hospital
Washington D.C., District of Columbia, United States, 20016
Actively Recruiting
3
George Washington University Hospital
Washington D.C., District of Columbia, United States, 20037
Actively Recruiting
4
Johns Hopkins Hospital Broadway Baltimore
Baltimore, Maryland, United States, 21205
Actively Recruiting
5
Johns Hopkins Hospital Bayview
Baltimore, Maryland, United States, 21224
Actively Recruiting
6
Johns Hopkins Hospital Greenspring
Baltimore, Maryland, United States, 21287
Actively Recruiting
7
Johns Hopkins Suburban Hospital
Bethesda, Maryland, United States, 20814
Actively Recruiting
8
Johns Hopkins Otolaryngology Clinic
Bethesda, Maryland, United States, 20817
Actively Recruiting
9
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
M
Melissa L Wheatley
C
Clint T Allen, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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