Actively Recruiting

Phase Not Applicable
Age: 18Years - 50Years
All Genders
NCT06244511

Bipedal vs. Unipedal Exercises in Chronic Ankle Instability

Led by Istanbul University - Cerrahpasa · Updated on 2025-03-24

40

Participants Needed

1

Research Sites

121 weeks

Total Duration

On this page

Sponsors

I

Istanbul University - Cerrahpasa

Lead Sponsor

B

Bezmialem Vakif University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Ankle sprain is a commonly encountered condition in clinical practice, constituting approximately 15-30% of all musculoskeletal injuries. Long-term studies have demonstrated that up to 73% of patients experience at least one more ankle sprain following an acute ankle sprain. Inadequate treatment of acute ankle instability can lead to chronic ankle instability (CAI) in 30-70% of cases. Treatment approaches for CAI are classified into conservative and surgical methods. Typically, conservative treatment is initially employed to address proprioceptive deficits and static impairments. Passive, unidirectional treatments such as injections, electrotherapy, and ice, which do not target muscle strength, kinetic chain, tendon capacity, and cortical control, are reported to be insufficient or ineffective in treating CAI, relying solely on symptomatic relief. Therefore, therapeutic exercises are fundamental in CAI treatment, leading to positive developments in parameters such as strength, dynamic balance, functional status, quality of life, and injury risk. Among the most commonly used exercise approaches are proprioceptive and resistive exercises. Upon reviewing the literature, it is observed that bipedal exercises have been employed from the early stages of CAI. However, due to clinical symptoms such as pain, insecurity, and fear associated with loading the affected limb, patients tend to avoid putting weight on the affected limb, resulting in the frequent use of bipedal exercises in the early phases of rehabilitation. The aim of this study is to comparatively examine the effectiveness of unipedal exercise interventions used in the early stages of rehabilitation for individuals with CAI in terms of pain, functional stability, fear avoidance, disease severity, functional performance, balance, and patient satisfaction, in comparison to bipedal exercise interventions.

CONDITIONS

Official Title

Bipedal vs. Unipedal Exercises in Chronic Ankle Instability

Who Can Participate

Age: 18Years - 50Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Documented unilateral ankle instability confirmed by clinical tests and MRI if needed
  • History of an initial ankle sprain at least 6 months ago
  • Recurrent sense of giving way starting at least 6 months ago and occurring intermittently
Not Eligible

You will not qualify if you...

  • History of previous surgery in the lower extremity
  • Presence of cartilage injuries, tendon tears, or impingement syndromes
  • Fracture accompanying foot-ankle instability
  • Congenital deformities in the foot-ankle
  • Diagnosis of talus osteochondral lesion
  • Diagnosis of ankle arthritis
  • Presence of medial ligament lesion
  • Presence of peripheral neuropathy
  • Additional rheumatological diseases
  • Regular moderate exercise at least 3 days per week in the last 6 months

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Acibadem Mehmet Ali Aydinlar University

Istanbul, Turkey (Türkiye), 34752

Actively Recruiting

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Research Team

A

Ayşenur Erekdağ, MSc

CONTACT

S

Sezen Karabörklü Argut, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Bipedal vs. Unipedal Exercises in Chronic Ankle Instability | DecenTrialz