Efficacy and safety of enucleation vs. resection of prostate for treatment of benign prostatic hyperplasia: a meta-analysis of randomized controlled trials.
Yucong Zhang, Penghui Yuan, Delin Ma...
https://pubmed.ncbi.nlm.nih.gov/30816336Actively Recruiting
Phase Not Applicable
Age: 50Years - 80Years
MALE
ID06983444
Bipolar Transurethral Resection Versus Bipolar Enucleation of the Prostate for Treatment of Benign Prostatic Hyperplasia: A Randomized Comparative Study
Led by South Valley University · Updated on 2025-05-21
100
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness and safety of two surgical methods for treating benign prostatic hyperplasia (BPH), a condition causing lower urinary tract symptoms due to prostate enlargement. The study compares the long-standing standard method, transurethral resection of the prostate (TURP), with a newer approach called bipolar transurethral enucleation of the prostate (TUEP). TURP has been effective but carries risks such as serious complications and longer hospital stays, prompting exploration of safer, minimally invasive options. The trial involves two treatment groups: one receiving TURP and the other receiving bipolar enucleation (TUEP). Both procedures use bipolar diathermy via cystoscopy and are performed under spinal or general anesthesia according to usual care. TURP removes excess prostate tissue piece by piece, whereas TUEP anatomically enucleates the prostate. The study will assess these treatments over at least six months to one year to understand differences in symptom relief and safety. Participants will be men aged 50 to 80 years with significant urinary symptoms and prostate enlargement requiring surgery. Researchers will monitor catheter use, urinary symptoms, operative time, complications, and quality of life using various questionnaires during follow-up visits. Outcomes such as catheter-free status and symptom scores will be evaluated up to one year after surgery to compare the treatments' benefits and risks.
CONDITIONS
Brief Title
Bipolar Resection vs Enucleation of Prostate
Who Can Participate
Age: 50Years - 80Years
MALE
Eligibility Criteria
You may qualify if you...
- Patients with lower urinary tract symptoms due to benign prostatic hyperplasia
- International prostate symptom score (IPSS) greater than 8
- Maximal urinary flow rate (Qmax) less than 10 ml/second
- Prostate volume between 60 and 100 grams
- Indication for surgical intervention
- Age between 50 and 80 years old
You will not qualify if you...
- Presence of prostate cancer
- Presence of bladder cancer
- Urethral stricture
- Neurogenic bladder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery and Immediate Post-operative Care
Duration - 60 to 90 minutes for surgery plus hospital stay duration
Participants receive either bipolar transurethral resection of the prostate (TURP) or bipolar transurethral enucleation of the prostate (TUEP) performed under spinal or general anesthesia as per usual care. This stage includes the surgery and immediate recovery period.
1 surgery visit and hospital stay
Post-operative Follow-up
Duration - At least 6 months up to one year
Participants are monitored to assess catheter removal, urinary symptoms, complications, and quality of life after surgery.
Multiple follow-up visits over 6 to 12 months
Trial Site Locations
Total: 1 location
1
Faculty of Medicine South Valley University
Qina, Qena Governorate, Egypt, 83523
Actively Recruiting
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Research Team
A
AHMED A.FATAH HAMED, Master's
M
Mostafa A.Razik Ahmed, Doctorate
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
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Michael Seitz, Ronald Sroka, Christian Gratzke...
https://pubmed.ncbi.nlm.nih.gov/17628326Photoselective vaporization (PVP) versus transurethral resection of the prostate (TURP): a prospective bi-centre study of perioperative morbidity and early functional outcome.
Alexander Bachmann, Leander Schürch, Robin Ruszat...
https://pubmed.ncbi.nlm.nih.gov/16126327Long-term results of a randomized trial comparing holmium laser enucleation of the prostate and transurethral resection of the prostate: results at 7 years.
Peter J Gilling, Liam C Wilson, Colleen J King...
https://pubmed.ncbi.nlm.nih.gov/21883820Bipolar endoscopic enucleation versus bipolar transurethral resection of the prostate: an ESUT systematic review and cumulative analysis.
Davide Arcaniolo, Celeste Manfredi, Alessandro Veccia...
https://pubmed.ncbi.nlm.nih.gov/31346761A prospective randomized study comparing monopolar and bipolar transurethral resection of prostate using transurethral resection in saline (TURIS) system.
Henry S S Ho, Sidney K H Yip, Kok B Lim...
https://pubmed.ncbi.nlm.nih.gov/17416453