Actively Recruiting
Birdshot Chorioretinopathy : Prospective Follow-up and Immunogenetic Studies(CO-BIRD)
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-03-04
600
Participants Needed
1
Research Sites
1365 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
U
URC-CIC Paris Descartes Necker Cochin
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is twofold: 1. To analyze the clinical features of a cohort of patients with birdshot chorioretinopathy (BCR), an inflammatory bilateral ocular disease, affecting the choroid and the retina. Various imaging techniques will be used to assess the effect of the disease on the retina and the choroid. A standardized assessment of the visual function will be performed with visual acuity, visual field and color vision testing. The quality of life of the patients will be evaluated with the VFQ-25 questionnaire. These analyses will help delineating different forms of the disease among its heterogeneous presentations. 2. To identify predisposing factors for the disease. The condition is unique from the immunogenetic standpoint by its association with the HLA-A29 allele, which is the strongest link between an HLA class I antigen and a disease. To date, however, the mechanisms leading to birdshot chorioretinopathy remain unknown. GWAS (Genome Wide association Study) based on DNA of the cohort patients will be performed with the aim to identify other susceptibility genes associated with BCR.
CONDITIONS
Official Title
Birdshot Chorioretinopathy : Prospective Follow-up and Immunogenetic Studies(CO-BIRD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Bilateral disease affecting both eyes
- Presence of at least three peripapillary birdshot lesions inferior or nasal to the optic disk in one eye
- Low-grade inflammation in the front part of the eye with 1+ cells or less in the anterior chamber
- Low-grade vitreous inflammatory reaction with 2+ vitreous haze or less
- Supportive findings including HLA-A29 positivity, retinal vasculitis, or cystoid macular edema
You will not qualify if you...
- Presence of keratic precipitates
- Presence of posterior synechiae
- Having infectious, neoplastic, or other inflammatory diseases that cause multifocal choroidal lesions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ophtalmopôle, Hôpital Cochin
Paris, Île-de-France Region, France, 75014
Actively Recruiting
Research Team
S
Souhila KECILI, MSc
CONTACT
G
Guillaume MASSON
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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