Study of Neuropathic Mechanisms in Tooth Pain Using Bite Force Measurements in Adults Needing Lower Molar Dental Treatment

What this Trial Is About

Researchers are investigating the neuropathic mechanisms behind acute dental pain caused by untreated tooth decay, specifically focusing on conditions like irreversible pulpitis, apical periodontitis, and pulpal necrosis. The study aims to better understand how nerve and surrounding tissue involvement produces pain through mechanisms such as mechanical allodynia and central sensitization. By identifying these pain pathways, the research hopes to support new non-opioid pain treatments and reduce reliance on opioids, especially in emergency room settings where dental care access is limited. This observational study uses the FDA-approved Innobyte4 device to measure bite force and quantify mechanical pain thresholds in patients needing endodontic treatment root canal therapy on lower molar teeth. Participants include those requiring restoration on vital molars, with pulpal involvement, or with irreversible pulpitis or necrosis, sometimes accompanied by tenderness or radiographic signs of apical pathology. The study groups include healthy controls and varying stages of pulp and apex health or disease. Participants will undergo assessments including measurements of mechanical allodynia and central sensitization before and 10 minutes after local anesthesia, as well as evaluations of tooth vitality and pain rating scores. The study requires the presence of an opposing tooth and adequate contact for bite testing. Data collected will help validate neuropathic pain as a target for improved dental pain management. Total participation details and follow-up durations are not specified.

Bite Force Measurements