Comparing Single Dose Versus 3-Day Nitrofurantoin to Prevent Urinary Tract Infections After Bladder Botox Injections for Overactive Bladder or Bladder Pain Syndrome

What this Trial Is About

Overactive bladder OAB and bladder pain syndrome ICBPS are common conditions that impact quality of life, affecting about 17% of people. This research evaluates different antibiotic plans to prevent urinary tract infections UTIs after intradetrusor onabotulinumtoxinA injections, a treatment for OAB and ICBPS. The study aims to find the best timing, duration, and type of antibiotic to reduce UTIs and limit unnecessary antibiotic use that can cause side effects and resistance. Participants will be randomly assigned to one of two groups one group will take a 3-day course of nitrofurantoin twice daily starting at the procedure time, and the other will take a single nitrofurantoin dose at the procedure time. Before the procedure, patients will have urine tests to ensure no current infection. On the day of treatment, patients will receive lidocaine and possibly diazepam for comfort, along with phenazopyridine and nitrofurantoin before the injection. The procedure follows standard medical guidelines. During the study, urine tests will be done if symptoms of UTI appear, and patients will be followed up 30 to 45 days after the procedure via phone, email, or messaging to check for UTIs and other outcomes. The main measure is the rate of UTIs within 30 days after the injection. Additional safety and symptom data will also be collected to evaluate the treatments. Participation will last through this follow-up period to monitor results.

Bladder Botox UTI Antibiotic Prophylaxis