Study of Bleeding Patterns with Sequential vs Continuous Progesterone in Adolescents with Turner Syndrome and Primary Ovarian Insufficiency

What this Trial Is About

Researchers are evaluating the effects of two different progesterone supplementation methods in adolescents and young women with Turner Syndrome who also have primary ovarian insufficiency and are prescribed hormone replacement therapy. This Phase 4, single-site, open-label, non-randomized study compares sequential versus continuous use of progesterone to understand differences in menstrual bleeding patterns. Participants receive either oral micronized progesterone 200 mg for the first 12 days of a 30 to 31-day cycle sequential supplementation or oral micronized progesterone 100 mg daily throughout the entire 30 to 31-day cycle continuous supplementation. Both regimens are studied over a 90-day treatment period. During the study, participants will track menstrual bleeding using the Pictorial Bleeding Assessment Chart, complete a menstrual distress questionnaire, and have endometrial thickness measured near the end of treatment. Researchers will assess these outcomes from enrollment through the 90-day treatment to understand how each progesterone regimen affects menstrual patterns and related symptoms.

Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome