Actively Recruiting
Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
Led by Hamilton Health Sciences Corporation · Updated on 2026-04-29
100
Participants Needed
3
Research Sites
103 weeks
Total Duration
On this page
Sponsors
H
Hamilton Health Sciences Corporation
Lead Sponsor
P
Population Health Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The BRACKETS pilot study is a multicentre, prospective, randomized controlled trial of prophylactic preoperative tranexamic acid (TXA) versus placebo and, using a partial factorial design, of prophylactic preoperative desmopressin versus placebo.
CONDITIONS
Official Title
Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Estimated glomerular filtration rate (eGFR) less than 25 ml/min/1.73m2 within the last 6 months or receipt of dialysis within the last 7 days
- Planned noncardiac surgery (elective, urgent, or emergency)
- Expected hospital stay of at least one night after surgery
- Provided informed consent to participate in the trial
- Included in the tranexamic acid factorial to be eligible for the desmopressin factorial
You will not qualify if you...
- Undergoing cardiac surgery
- Undergoing intracranial neurosurgery
- Undergoing surgery to create or revise arteriovenous fistula or graft for dialysis access
- Planned use of prophylactic systemic tranexamic acid or epsilon-aminocaproic acid
- Known allergy or hypersensitivity to tranexamic acid or desmopressin
- History of seizure disorder
- Recent stroke, heart attack, arterial thrombosis, deep vein thrombosis, pulmonary embolism, or thrombosis of an arteriovenous fistula or graft within 90 days
- History of thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome, or antiphospholipid antibody syndrome
- Women who are pregnant, breastfeeding, or of childbearing potential without recent negative pregnancy test and not using effective contraception
- Hospital lacks access to desmopressin
- Planned use of prophylactic desmopressin
- Serum sodium concentration below 130 mEq/L
- Known or suspected von Willebrand disease, hemophilia, or platelet function disorder
- Previously enrolled in the BRACKETS-Pilot Trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
London Health Sciences Centre
London, Ontario, Canada, N6A 5A5
Actively Recruiting
2
Centre Hospitalier de L'Universite de Montreal (CHUM)
Montreal, Quebec, Canada, H2X 0A9
Active, Not Recruiting
3
McGill University University Health Centre
Montreal, Quebec, Canada, H3H 2R9
Active, Not Recruiting
Research Team
I
Ingrid Copland
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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