Actively Recruiting
BLOCK-study: Better Local Orthopedic Pain Control After Knee Arthroplasty
Led by Jessa Hospital · Updated on 2025-02-20
210
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to compare the anesthetic combination iPACK with femoral triangle block versus surgical LIA for unilateral TKA. We hypothesize that an iPACK block with femoral triangle block is non-inferior to surgical LIA. Furthermore, due to visualization of the relevant neural and vascular structures, the risk of accidental popliteal block, nerve damage or LAST with (a blindly performed) LIA could theoretically be reduced.
CONDITIONS
Official Title
BLOCK-study: Better Local Orthopedic Pain Control After Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA physical status I to III
- Body mass index between 17 and 35 kg/m2
- Ability to give informed consent
- Scheduled for unilateral total knee arthroplasty
You will not qualify if you...
- Patient refusal to participate
- Inability to communicate due to language or neurological issues
- Bilateral or non-unilateral knee arthroplasty
- Chronic opioid use or chronic pain patients
- Use of atypical analgesics like gabapentin or pregabalin
- History of Sudeck atrophy
- More than three chronic pain consultations
- Contraindications for spinal anesthesia
- Local infection
- Abnormal blood clotting per ESRA guidelines
- Severe spinal canal stenosis
- Intracranial hypertension
- Previous neurological injury in the affected limb
- Contraindications or allergies to local anesthetics
- Absolute contraindications or allergies to NSAIDs or paracetamol
- Severe kidney impairment (eGFR less than 30 ml/min/1.73 m2)
- Active or recent gastric ulcers, perforations, or bleeding within 6 months
- Crohn's disease or ulcerative colitis
- Liver function impairment
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Jessa Hospital
Hasselt, Limburg, Belgium, 3500
Actively Recruiting
Research Team
B
Bjorn Stessel, MD, PhD
CONTACT
I
Ina Callebaut, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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