What is this study trying to find out about restless legs syndrome?

This study is exploring how exercise changes proteins in the blood of people with restless legs syndrome (RLS) to better understand the causes of RLS. Sponsored by Stanford University, the research compares long-term exercise effects to no exercise. Participants can expect to provide blood samples and complete exercise tests during the trial.

Who may be eligible for this restless legs syndrome clinical trial?

Adults aged 18 or older with a diagnosis of moderate-to-severe restless legs syndrome who are currently untreated may be eligible. The study requires participants to be mostly inactive and able to walk without assistance. Please review eligibility criteria for more details.

Is there any cost to participate in this restless legs syndrome clinical trial?

Study-related care, including the exercise program and all trial visits, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly for any travel needs.

Actively Recruiting

Phase Not Applicable

Age: 18Years +

All Genders

ID06481176

How Exercise Affects Blood Proteins in Adults with Restless Legs Syndrome Over 12 Weeks

Led by Stanford University · Updated on 2024-11-27

Participants Needed

Research Sites

17 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating how exercise affects molecules in the blood of adults with restless legs syndrome RLS to better understand what causes this condition. The study aims to find out how long-term exercise and a single exercise session change protein levels in the blood. Participants will be assigned to either an exercise group or a no-exercise group to compare these effects. Participants in the exercise group will follow a 12-week program specifically designed for people with RLS. This program includes strength training, cardiovascular exercise like walking or bicycling, and stretching sessions three times per week. Those in the no-exercise group will not receive any intervention or interaction during the same 12-week period. Both groups will complete exercise tests and provide blood samples before and after the program. Throughout the study, participants will undergo assessments including blood protein analysis and measures of RLS severity, cardiorespiratory fitness, and sleep patterns at the start and after 12 weeks. The researchers will monitor changes in protein expression profiles twice at baseline and twice at the 12-week follow-up. This will help determine the effects of exercise on RLS symptoms and related biological markers.

CONDITIONS

Brief Title

Blood Changes After Exercise in Restless Legs Syndrome

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Age 18 years or older
Diagnosis of restless legs syndrome (RLS)
Moderate-to-severe RLS with IRLS score greater than 15
Currently untreated for RLS
Not regularly active (less than 30 minutes of activity on more than 2 days per week during past 6 months)
Ability to walk without assistance (no cane, walker, or wheelchair use)
Willingness to complete outcome measures and exercise program

You will not qualify if you...

Conditions that mimic or cause secondary RLS such as iron deficiency anemia, radiculopathy, peripheral edema, peripheral neuropathy, or diabetes
Moderate or high risk for strenuous or maximal exercise

Research Team

Katie Cederberg, PhD

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