Actively Recruiting
Blood Donor CVD 5000
Led by University of Maryland, Baltimore · Updated on 2026-03-27
150
Participants Needed
1
Research Sites
1380 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an open-label, non-randomized study. Volunteers will be vaccinated with the typhoid oral vaccine, Vivotif. Vivotif has been licensed by the Food and Drug Administration (FDA) for travelers to developing countries. Volunteers will also be asked to provide blood, saliva, and stool specimens over a follow-up time period of up to eight years. The specimens obtained in this clinical research study will be used to further the investigator's understanding of the protective immunological mechanisms that can be elicited systemically and may be applicable to other enteric pathogens.
CONDITIONS
Official Title
Blood Donor CVD 5000
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years and older
- Good general health as determined by a screening evaluation within 28 days before blood donation
- Informed, written consent
You will not qualify if you...
- History of diabetes
- Cancer in past 5 years (except basal cell carcinoma of the skin and cervical carcinoma in situ)
- Heart disease including hospitalization for heart attack, bypass surgery, arrhythmia, or syncope within past 5 years
- Current symptoms of heart disease such as dyspnea, angina, or orthopnea
- Recurrent infections with more than 3 hospitalizations for invasive bacterial infections like pneumonia or meningitis
- Current drug or alcohol abuse
- Active ulcer disease or ongoing intestinal condition
- Treatment for anemia in last 6 months
- Currently being treated with anti-malarial drugs
- White blood cell count outside specified normal limits
- Hemoglobin outside specified normal limits
- Platelet count outside specified normal limits
- Abnormal liver enzymes (SGOT or SGPT greater than 1.5 times normal)
- Positive serology for hepatitis C, HIV antibody, hepatitis B surface antigen, or hepatitis B core antibody
- Poor peripheral venous access for blood donation
- Positive Rapid Plasma Reagin (RPR) test
- Any condition that would jeopardize volunteer safety or study integrity
- Positive urine pregnancy test on day of vaccination or pregnancy indicated by menstrual history prior to blood donation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Maryland, Baltimore, Center for Vaccine Development and Global Health
Baltimore, Maryland, United States, 21201
Actively Recruiting
Research Team
S
Susan Holian, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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