Actively Recruiting
Blood Flow Regulation and Neuromuscular Function Post-Stroke
Led by Medical College of Wisconsin · Updated on 2025-09-25
40
Participants Needed
2
Research Sites
233 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.
CONDITIONS
Official Title
Blood Flow Regulation and Neuromuscular Function Post-Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be between 18-85 years of age
- Able to give informed consent
- At least 6 months post diagnosis of unilateral cortical or sub-cortical stroke
- English speaking
You will not qualify if you...
- History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg)
- Chronic pain syndrome
- Low back or hip pain that interferes with lower extremity motor testing
- History of head trauma
- Comorbid neurological disorder
- Peripheral vascular disease
- Myocardial infarction in the previous year
- Inability to follow 2 step commands
- Condition where fatiguing contractions or resisted leg contractions are contraindicated
- Resting systolic blood pressure 60 mmHg or diastolic blood pressure 110 mmHg
- Pregnancy or breastfeeding.
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
2
Marquette University
Milwaukee, Wisconsin, United States, 53233
Actively Recruiting
Research Team
M
Matthew Durand, Ph.D.
CONTACT
J
Jennifer Nguyen, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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