Actively Recruiting
Blood Flow Restriction for Optimizing Balance in Parkinson's Disease
Led by The University of Texas Health Science Center at San Antonio · Updated on 2026-03-31
20
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center at San Antonio
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to understand how reducing blood flow (BRT) during balance-challenging strengthening exercises (instability resistance training, or IRT) can help improve symptoms of Parkinson's disease.
CONDITIONS
Official Title
Blood Flow Restriction for Optimizing Balance in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females between the ages 40 and 85 with a diagnosis of idiopathic Parkinson's Disease consistent with the United Kingdom PD society brain bank criteria
- Hoehn and Yahr stage 2-4
- Mini-Mental Scale Examination score of 23 or higher
You will not qualify if you...
- History of cardiovascular disease, uncontrolled hypertension (blood pressure 140/90 mmHg or higher), orthostatic hypotension, deep-vein thrombosis, varicose veins, or rhabdomyolysis
- Ankle branchial index less than or equal to 0.9 or greater than 1.3
- History of other neurological disorders affecting the central nervous system such as stroke, multiple sclerosis, tumors, amyotrophic lateral sclerosis, or muscle diseases like muscular dystrophy or myopathy
- History of uncontrolled diabetes, severe osteoporosis, or cognitive impairment
- Body mass index above 40
- Absolute contraindications to exercise per American College of Sports Medicine guidelines including uncontrolled arrhythmias, third-degree heart block, recent electrocardiogram changes, unstable angina, acute myocardial infarction, or acute congestive heart failure
- Surgery on lower extremities within the past 6 months
- Pre-menopausal and not on birth control
- Pregnant or planning to become pregnant during the study
- Planning major surgery within 2 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
Research Team
A
Anjali Sivaramakrishnan, PhD, PT
CONTACT
A
Alyssa Main
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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